4569-86-2

4569-86-2 structure

Name: ci 50206
Chemical Name: 2-N,2-N-diethyl-10-phenylphenazin-10-ium-2,8-diamine,chloride
CAS Number: 4569-86-2
Molecular Formula: C₂₂H₂₃ClN₄
Molecular Weight: 378.89800
Catalog: Biochemical Biochemical reagent Biological dye
Create Date: 2018-10-08 17:12:19
Modify Date: 2024-01-08 18:39:48
Methylene Violet 3RAX is a phenazine dye to stain the mitochondria of cells. Methylene Violet 3RAX can change the molecular structure of DNA, undermine the module of DNA, and induce the generation of the reactive singlet oxygen. Methylene Violet 3RAX shows inhibition for human erythrocyte AChE and human plasma BChE with an Kis of 1.58, 0.51 μM, respectively. Methylene Violet 3RAX has the potential for the research of potential photosensitizers for mitochondrial targeting action in PDT (photodynamic therapy)[1][2].

Name	2-N,2-N-diethyl-10-phenylphenazin-10-ium-2,8-diamine,chloride
Synonyms	Methylene violet 3RAX 3-amino-7-N,N-diethylamino-2-methyl-5-phenyl-phenazinium chloride MFCD00013433 3-amino-7-diethylamino-5-phenyl-phenazinium,chloride methylene violet N,N-Diethylphenosafranine 3-Amino-7-diaethylamino-5-phenyl-phenazinium,Chlorid

Description	Methylene Violet 3RAX is a phenazine dye to stain the mitochondria of cells. Methylene Violet 3RAX can change the molecular structure of DNA, undermine the module of DNA, and induce the generation of the reactive singlet oxygen. Methylene Violet 3RAX shows inhibition for human erythrocyte AChE and human plasma BChE with an Kis of 1.58, 0.51 μM, respectively. Methylene Violet 3RAX has the potential for the research of potential photosensitizers for mitochondrial targeting action in PDT (photodynamic therapy)[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Neuronal Signaling >> AChE
Target	Acetylcholinesterase:1.58 μM (Ki) Butyrylcholinesterase:0.51 μM (Ki)
In Vitro	Methylene Violet 3RAX shows antitumor activity by cutting off DNA strands in tumour cell[1].Methylene Violet 3RAX (0-400 µM) significantly enhances cleavage of DNA with over 60% photocleavage activity towards DNA at 300 μM[1].
References	[1]. Si Yao, et al. Methylene violet 3RAX-conjugated porphyrin for photodynamic therapy: synthesis, DNA photocleavage, and cell study. RSC Advances. 2022,12, 21004-21013. [2]. Onder S, et al. The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by methylene violet 3RAX. Chem Biol Interact. 2019 Dec 1;314:108845.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%