151271-53-3

151271-53-3 structure

Name: UK-1
Chemical Name: methyl 2-[2-(6-oxocyclohexa-2,4-dien-1-ylidene)-3H-1,3-benzoxazol-4-yl]-1,3-benzoxazole-4-carboxylate
CAS Number: 151271-53-3
Molecular Formula: C₂₂H₁₄N₂O₅
Molecular Weight: 386.35700
Create Date: 2016-05-25 06:03:41
Modify Date: 2025-09-18 19:29:19
UK-1 is a cytotoxic metabolite from Streptomyces sp. 517-02 and exerts a wide spectrum of potent anticancer activities[1]. UK-1 also inhibits HCV replication[2].

Name	methyl 2-[2-(6-oxocyclohexa-2,4-dien-1-ylidene)-3H-1,3-benzoxazol-4-yl]-1,3-benzoxazole-4-carboxylate
Synonyms	[2,4'-Bibenzoxazole]-4-carboxylicacid,2'-(2-hydroxyphenyl)-,methyl ester 2'-(2-hydroxyphenyl)-2,4'-bibenzoxazole-4-carboxylic acid methyl ester UK 1(cytotoxin) UK 1

Description	UK-1 is a cytotoxic metabolite from Streptomyces sp. 517-02 and exerts a wide spectrum of potent anticancer activities[1]. UK-1 also inhibits HCV replication[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Anti-infection >> HCV Research Areas >> Infection
References	[1]. Ueki M, et al. UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties. J Antibiot (Tokyo). 1993 Jul;46(7):1089-94. [2]. Ward DN, et al. UK-1 and structural analogs are potent inhibitors of hepatitis C virus replication. Bioorg Med Chem Lett. 2014 Jan 15;24(2):609-12.