136647-02-4
136647-02-4 structure
- Name: UK-78282 Hydrochloride
- Chemical Name: 4-(benzhydryloxymethyl)-1-[3-(4-methoxyphenyl)propyl]piperidine,hydrochloride
- CAS Number: 136647-02-4
- Molecular Formula: C29H36ClNO2
- Molecular Weight: 466.05
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
- Create Date: 2018-11-25 00:04:01
- Modify Date: 2025-08-25 14:16:23
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UK-78282, a novel piperidine, potent and selective Kv1.3 blocker with an IC50 of 200 nM. UK-78,282 effectively suppresses human T-lymphocyte activation in vitro. UK-78,282 binds to residues at the inner surface of the channel overlapping the site of action of verapamil[1].
| Name | 4-(benzhydryloxymethyl)-1-[3-(4-methoxyphenyl)propyl]piperidine,hydrochloride |
|---|---|
| Synonyms |
4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidinehydrochloride
4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidine monohydrochloride |
| Description | UK-78282, a novel piperidine, potent and selective Kv1.3 blocker with an IC50 of 200 nM. UK-78,282 effectively suppresses human T-lymphocyte activation in vitro. UK-78,282 binds to residues at the inner surface of the channel overlapping the site of action of verapamil[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 200 nM (Kv1.3)[1] |
| References |
| Molecular Formula | C29H36ClNO2 |
|---|---|
| Molecular Weight | 466.05 |
| Exact Mass | 465.24300 |
| PSA | 21.70000 |
| LogP | 6.88590 |
| Storage condition | -20°C |
| Symbol |
GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319-H400 |
| Precautionary Statements | P273-P305 + P351 + P338 |
| RIDADR | UN 3077 9 / PGIII |
| HS Code | 2933399090 |
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |