Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Hydroxypropyl-β-cyclodextrin
Price: ￥118.0/25g ￥348.0/100g
Purity: 97.0%
Stocking Period: Inquiry
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (2-HYDROXYPHENYL)(1-PHENYL-1H-PYRAZOL-4-YL)METHANONE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: 2-Hydroxypropyl-cyclodextrin
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: (2-Hydroxypropyl)-β-cyclodextrin
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

128446-35-5

128446-35-5 structure

128446-35-5 structure

Name: Hydroxypropyl-β-cyclodextrin
Chemical Name: (2-Hydroxypropyl)-β-cyclodextrin
CAS Number: 128446-35-5
Molecular Formula: C₆₃H₁₁₂O₄₂
Molecular Weight: 1541.538
Catalog: Biochemical Carbohydrate Polysaccharide
Create Date: 2018-08-28 19:12:09
Modify Date: 2024-01-02 00:35:54
(2-Hydroxypropyl)-β-cyclodextrin is a widely used drug delivery vehicle to improve the stability and bioavailability.

Name	(2-Hydroxypropyl)-β-cyclodextrin
Synonyms	(2-Hydroxypropyl)-Beta-Cyclodextrin EINECS 420-920-1 MFCD00069372 Hydroxypropyl-beta-cyclodextrin (2-HYDROXYPROPYL)-β-CYCLODEXTRIN (2-Hydroxypropyl)-Beta-Cyclodextri Hydroxypropyl-β-cyclodextrin

Description	(2-Hydroxypropyl)-β-cyclodextrin is a widely used drug delivery vehicle to improve the stability and bioavailability.
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cancer
In Vitro	Cell treatment with (2-Hydroxypropyl)-β-cyclodextrin results in the activation of the transcription factor EB, a master regulator of lysosomal function and autophagy, and in enhancement of the cellular autophagic clearance capacity[1]. (2-Hydroxypropyl)-β-cyclodextrin treatment reduces intracellular cholesterol resulting in significant leukemic cell growth inhibition through G2/M cell-cycle arrest and apoptosis. The IC50 values for (2-Hydroxypropyl)-β-cyclodextrin after 72 hours exposure are in the range of 3.86–10.09 mM. (2-Hydroxypropyl)-β-cyclodextrin also shows anticancer effects against CML cells expressing a T315I BCR-ABL mutation (that confers resistance to most ABL tyrosine kinase inhibitors), and hypoxia-adapted CML cells that have characteristics of leukemic stem cells. In addition, colony forming ability of human primary AML and CML cells is inhibited by (2-Hydroxypropyl)-β-cyclodextrin[2].
In Vivo	(2-Hydroxypropyl)-β-cyclodextrin administration promotes transcription factor EB-mediated clearance of proteolipid aggregates that accumulate due to inefficient activity of the lysosome-autophagy system in cells derived from a patient with a lysosomal storage disorder[1]. Intraperitoneal injection of (2-Hydroxypropyl)-β-cyclodextrin significantly improves survival in leukemia mouse models. Systemic administration of (2-Hydroxypropyl)-β-cyclodextrin to mice has no significant adverse effects[2].
Cell Assay	Cells are incubated with (2-Hydroxypropyl)-β-cyclodextrin at various concentrations (5, 7.5, 10, 15, 20 mM) for 72 hours. Cell viability is assessed using a trypan blue dye exclusion method and cell proliferation is evaluated using a modified methyl-thiazol-diphenyl- tetrazolium (MTT) assay[2].
Animal Admin	Mice: Mice are intraperitoneally injected with 200 μL vehicle (saline) or (2-Hydroxypropyl)-β-cyclodextrin (50 or 150 mM) for 20 consecutive days 3 days after transplantation, and survival is monitored daily. Leukemic cell engraftment is confirmed by detection of GFP-positive cells in the recipient’s BM using flow cytometry[2].
References	[1]. Song W, et al. 2-Hydroxypropyl-β-cyclodextrin promotes transcription factor EB-mediated activation of autophagy: implications for therapy. J Biol Chem. 2014 Apr 4;289(14):10211-22. [2]. Yokoo M, et al. 2-Hydroxypropyl-β-Cyclodextrin Acts as a Novel Anticancer Agent. PLoS One. 2015 Nov 4;10(11):e0141946.

Density	1.4±0.1 g/cm3
Boiling Point	1521.9±60.0 °C at 760 mmHg
Melting Point	278ºC (dec.)
Molecular Formula	C₆₃H₁₁₂O₄₂
Molecular Weight	1541.538
Flash Point	874.2±32.9 °C
Exact Mass	1540.662842
PSA	618.66000
LogP	-6.23
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.545
Storage condition	2-8°C
Water Solubility	H2O: 45 % (w/v) \| Soluble in water.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	GU2293332