375345-95-2
375345-95-2 structure
- Name: Mibampator
- Chemical Name: N-[(2R)-2-[4-[4-[2-(methanesulfonamido)ethyl]phenyl]phenyl]propyl]propane-2-sulfonamide
- CAS Number: 375345-95-2
- Molecular Formula: C21H30N2O4S2
- Molecular Weight: 438.604
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
- Create Date: 2017-04-15 11:00:51
- Modify Date: 2025-08-25 13:23:11
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Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors.
| Name | N-[(2R)-2-[4-[4-[2-(methanesulfonamido)ethyl]phenyl]phenyl]propyl]propane-2-sulfonamide |
|---|---|
| Synonyms |
Mibampator
2-Propanesulfonamide, N-[(2R)-2-[4'-[2-[(methylsulfonyl)amino]ethyl][1,1'-biphenyl]-4-yl]propyl]- UNII-A9V5BW73UU N-[(2R)-2-(4'-{2-[(Methylsulfonyl)amino]ethyl}-4-biphenylyl)propyl]-2-propanesulfonamide 2-propanesulfonamide LY451395 |
| Description | Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors. |
|---|---|
| Related Catalog | |
| Target |
AMPA receptor[1]. |
| In Vivo | Incubation of Mibampator (LY451395) with Actinoplanes missouriensis NRRL B3342 generated several metabolites that were previously detected in the in vivo metabolism studies of the preclinical species [1]. LY404187 and Mibampator (LY451395) reverses the central effects of an acutely intoxicating dose of ethanol in the rat. Mibampator (LY451395) significantly and dose-dependently reversed ethanol-induced deficits in both motor coordination and disruptions in an operant task where animals were trained to press a lever for food reward [2]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 609.4±65.0 °C at 760 mmHg |
| Molecular Formula | C21H30N2O4S2 |
| Molecular Weight | 438.604 |
| Flash Point | 322.4±34.3 °C |
| Exact Mass | 438.164703 |
| PSA | 109.10000 |
| LogP | 3.25 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.562 |
| Storage condition | 2-8℃ |
|
~93%
375345-95-2 |
| Literature: Miller, William D.; Fray, Andrew H.; Quatroche, John T.; Sturgill, Christa D. Organic Process Research and Development, 2007 , vol. 11, # 3 p. 359 - 364 |
|
~77%
375345-95-2 |
| Literature: Arnold, Macklin Brian; Bleisch, Thomas John; Cuff, George William; Ornstein, Paul Leslie; Zimmerman, Dennis Michael Patent: US2003/225163 A1, 2003 ; Location in patent: Page 12-13 ; |
|
~99%
375345-95-2 |
| Literature: Miller, William D.; Fray, Andrew H.; Quatroche, John T.; Sturgill, Christa D. Organic Process Research and Development, 2007 , vol. 11, # 3 p. 359 - 364 |
|
~%
375345-95-2 |
| Literature: Miller, William D.; Fray, Andrew H.; Quatroche, John T.; Sturgill, Christa D. Organic Process Research and Development, 2007 , vol. 11, # 3 p. 359 - 364 |
|
~%
375345-95-2 |
| Literature: Miller, William D.; Fray, Andrew H.; Quatroche, John T.; Sturgill, Christa D. Organic Process Research and Development, 2007 , vol. 11, # 3 p. 359 - 364 |
| Precursor 5 | |
|---|---|
| DownStream 0 | |