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9004-99-3

9004-99-3 structure
9004-99-3 structure
Name Polyethylene Glycol Monostearate N-2
Synonyms Ethylene glycol, monostearate
Stearic acid, 2-hydroxyethyl ester
MFCD00151755
2-Hydroxyethyl octadecanoate
2-Hydroxyethyl stearate
ETHYLENE GLYCOL MONOSTEARATE
Octadecanoic acid, 2-hydroxyethyl ester
Poly(oxy-1,2-ethanediyl), .α.-hydro-.ω.-hydroxy-, octadecanoate
Polyoxyethylene stearate
Description Polyoxyethylene stearate (POES) is a non-ionic emulsifying agent.
Related Catalog
In Vitro Polyoxyethylene stearate has been recommended as an additive to the radiolabelled 7H12 Middlebrook TB media and as such has been shown to enhance growth of mycobacteria in the radiometric BACTEC rapid culture system. Polyoxyethylene (50) stearate produces the greatest enhancement in growth and reduction in the time taken to detect growth for M. tuberculosis and polyoxyethylene (30) stearate and polyoxyethylene (JL) stearate for species of mycobacteria other than M. tuberculosis[1]. Polyoxyethylene stearate inhibits P-gp mediated efflux in a concentration dependent manner mainly by modulating substrate-stimulated P-gp ATPase activity[2]. Polyoxyethylene 40 stearate reduces vinblastine sulfate efllux. The cytotoxicity of vinblastine to K562/ADR cells is significantly enhanced when the cells are cotreated with 100 or 150 μg/mL polyoxyethylene 40 stearate[3].
In Vivo Polyoxyethylene stearate is potentially useful as a pharmaceutical ingredient to improve the oral bioavailability of coadministered P-gp substrates and substrates for certain CYP isoforms[2]. The average tumor volume and average tumor weight are significantly less in the polyoxyethylene 40 stearate+vinblastine group. The inhibition rate for tumor growth is increased from 0.06 (vinblastine group) to 0.84 (vinblastine+polyoxyethylene 40 stearate group)[3].
Cell Assay Polyoxyethylene 40 stearate is added to the test vinblastine solution. The cytotoxicity of vinblastine to K562/ADR cells is then assessed. The final concentrations of polyoxyethylene 40 stearate are 0, 50, 100, and 150 μg/mL. After 8 hours of treatment, cells are incubated for 4 hours in the presence of MTT reagent and then lysed with DMSO. Absorbance is measured at 490 nM[3].
Animal Admin Mice: Polyoxyethylene 40 stearate and vinblastine are dissolved in 0.9% sodium chloride solution, yielding a solution of 200 μg/mL VBL and 150 μg/mL PS40. The drug is injected subcutaneously in a volume of 0.1 mL per 10 g of body weight at a dosage of 2 mg/kg vinblastine and 1.5 mg/kg polyoxyethylene 40 stearate around the tumor every other day for 8 days. The volume of tumors and the weight of mice are measured every day from the day the tumors are formed[3].
References

[1]. Cutler RR, et al. The effect of polyoxyethylene stearate (POES) on the growth of mycobacteria in radiometric 7H12 Middlebrook TB medium. Tubercle. 1987 Sep;68(3):209-20.

[2]. Zhu S, et al. Effects of polyoxyethylene (40) stearate on the activity of P-glycoprotein and cytochrome P450. Eur J Pharm Sci. 2009 Jul 12;37(5):573-80.

[3]. Luo L, et al. Polyoxyethylene 40 stearate modulates multidrug resistance and enhances antitumor activity of vinblastine sulfate. AAPS J. 2007 Oct 5;9(3):E329-35.
Density 0.9±0.1 g/cm3
Boiling Point 438.4±18.0 °C at 760 mmHg
Melting Point 47ºC
Molecular Formula C20H40O3
Molecular Weight 328.530
Flash Point 164.6±14.0 °C
Exact Mass 328.297760
PSA 46.53000
LogP 7.85
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.457

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TQ5950000
CHEMICAL NAME :
Polyethylene glycol monostearate #6000
CAS REGISTRY NUMBER :
9004-99-3
LAST UPDATED :
199710
DATA ITEMS CITED :
6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80463 No. of Facilities: 2667 (estimated) No. of Industries: 8 No. of Occupations: 10 No. of Employees: 40362 (estimated) NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81475 No. of Facilities: 1026 (estimated) No. of Industries: 7 No. of Occupations: 6 No. of Employees: 15937 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X8317 No. of Facilities: 9882 (estimated) No. of Industries: 71 No. of Occupations: 99 No. of Employees: 608690 (estimated) No. of Female Employees: 461354 (estimated)
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS MD0907300

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