71751-77-4
71751-77-4 structure
- Name: Meleagrin
- Chemical Name: meleagrine
- CAS Number: 71751-77-4
- Molecular Formula: C23H23N5O4
- Molecular Weight: 433.46000
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2016-12-11 02:00:59
- Modify Date: 2025-08-24 21:40:44
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Meleagrin is a roquefortine C-derived alkaloid produced by fungi of the genus Penicillium and has antimicrobial and anti-proliferative activities. Meleagrin is a class of FabI inhibitor. Meleagrin is a lead c-Met inhibitory entity useful for the control of c-Met-dependent metastatic and invasive breast malignancies[1][2][3].
| Name | meleagrine |
|---|---|
| Synonyms |
[3E,7aR,12aS,(-)]-7a-(1,1-Dimethyl-2-propenyl)-7a,12-dihydro-6-hydroxy-3-(1H-imidazole-4-ylmethylene)-12-methoxy-1H,5H-imidazo[1',2':1,2]pyrido[2,3-b]indole-2(3H),5-dione
8,9-dehydroneoxaline MELEAGRIN Meleagrine |
| Description | Meleagrin is a roquefortine C-derived alkaloid produced by fungi of the genus Penicillium and has antimicrobial and anti-proliferative activities. Meleagrin is a class of FabI inhibitor. Meleagrin is a lead c-Met inhibitory entity useful for the control of c-Met-dependent metastatic and invasive breast malignancies[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | Meleagrin inhibits the growth of the human breast cancer cell lines MDA-MB-231, MDA-468, BT-474, SK BR-3, MCF7 and MCF7-dox[3]. Meleagrin causes a dose-dependent inhibition of HGF-induced cell migration, and invasion of breast cancer cell lines[3]. |
| In Vivo | Meleagrin potently suppresses the invasive triple negative breast tumor cell growth in an orthotopic athymic nude mice model[3]. |
| References |
| Density | 1.47g/cm3 |
|---|---|
| Molecular Formula | C23H23N5O4 |
| Molecular Weight | 433.46000 |
| Exact Mass | 433.17500 |
| PSA | 110.79000 |
| LogP | 2.68160 |
| Index of Refraction | 1.717 |
| Hazard Codes | Xi |
|---|---|
| RIDADR | NONH for all modes of transport |
| Precursor 1 | |
|---|---|
| DownStream 0 | |