- GL Biochem (Shanghai) Ltd.
- China
- Product Name: Calmodulin-Dependent Protein Kinase II (290-309);LKKFNARRKLKGAILTTMLA
- Price: $Inquiry/1g
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Jackie Yang
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: Calmodulin-Dependent Protein Kinase II (290 - 309)
- Price: $Inquiry/1kg
- Purity: 99.0%
- Stocking Period: 1 Day
- Contact: Vinnie
115044-69-4
115044-69-4 structure
- Name: Calmodulin-Dependent Protein Kinase II (290-309)
- Chemical Name: Calmodulin-Dependent Protein Kinase II (290-309)
- CAS Number: 115044-69-4
- Molecular Formula: C103H185N31O24S
- Molecular Weight: 2273.83000
- Catalog: Peptides
- Create Date: 2016-07-06 12:21:16
- Modify Date: 2024-01-11 19:02:52
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Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II.
| Name | Calmodulin-Dependent Protein Kinase II (290-309) |
|---|---|
| Synonyms |
CAM KINASE II (290-309)
CALMODULIN-DEPENDENT PROTEIN KINASE II (290-309) CaM kinase II (290-309) CALMODULIN-DEPENDENT PROTEIN KINASE II FRAGMENT 290-309 LKKFNARRKLKGAILTTMLA CALMODULIN DEPENDENT PROTEIN KINASE II CALMODULIN BINDING DOMAIN LEU-LYS-LYS-PHE-ASN-ALA-ARG-ARG-LYS-LEU-LYS-GLY-ALA-ILE-LEU-THR-THR-MET-LEU-ALA CA2+/CALMODULIN-DEPENDENT PROTEIN KINASE II (290-309) CALMODULIN-DEPENDENT PROTEIN KINASE IIFR AGMENT 290 H-LEU-LYS-LYS-PHE-ASN-ALA-ARG-ARG-LYS-LEU-LYS-GLY-ALA-ILE-LEU-THR-THR-MET-LEU-ALA-OH |
| Description | Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II. |
|---|---|
| Related Catalog | |
| Target |
IC50: 52 nM (calmodulin-dependent protein kinase II)[1] |
| In Vitro | Peptide 290 to 309 is found to be a potent calmodulin antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase. Neither truncation from the amino terminus (peptide 296-309) nor extension in the carboxyl-terminal direction (peptide 294-319) markedly affects calmodulin binding, whereas shortening the peptide from the carboxyl terminus (peptide 290-302) or from both ends (peptide 295-304) results in the elimination of this activity[1]. |
| Kinase Assay | Ca2+/CaM-dependent phosphodiesterase is assayed at 30°C. The reaction mixture contains 40 mM Tris-HCl, pH 8.0, 5 mM magnesium acetate, 1 mM calcium chloride, 30 μM cGMP, 0.15 pCi of [3H]cGMP, 1 mM dithiothreitol, 20% glycerol, 0.64 mg/mL bovine serum albumin, 2.38 nM CaM, 50 pM CaM-deficient phosphodiesterase, and various concentrations of Calmodulin-Dependent Protein Kinase II (290-309). Following preincubation of the reaction mixture at 30°C, the reaction is initiated by the addition of substrate. After 50 min the reaction is terminated by boiling. Conditions are selected in which the reactions are linear with respect to time[1]. |
| References |
| Molecular Formula | C103H185N31O24S |
|---|---|
| Molecular Weight | 2273.83000 |
| Exact Mass | 2272.39000 |
| PSA | 952.95000 |
| LogP | 7.21720 |
| Storage condition | 2-8℃ |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |