913376-84-8
913376-84-8 structure
- Name: AMG-1
- Chemical Name: 1H-Pyrazole-4-carboxamide, N-[3-fluoro-4-[(7-methoxy-4-quinolinyl)oxy]phenyl]-2,3-dihydro-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl
- CAS Number: 913376-84-8
- Molecular Formula: C31H29FN4O5
- Molecular Weight: 556.584
- Create Date: 2017-11-17 02:40:40
- Modify Date: 2025-08-28 15:07:20
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AMG-1 is a potent inhibitor of human c-Met and RON with IC50 values of 4 and 9 nmol/L respectively.
| Name | 1H-Pyrazole-4-carboxamide, N-[3-fluoro-4-[(7-methoxy-4-quinolinyl)oxy]phenyl]-2,3-dihydro-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl |
|---|---|
| Synonyms |
N-[3-Fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl]-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide
MET/RON DUAL KINASE INHIBITOR 1H-Pyrazole-4-carboxamide, N-[3-fluoro-4-[(7-methoxy-4-quinolinyl)oxy]phenyl]-2,3-dihydro-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl- N-{3-Fluoro-4-[(7-methoxy-4-quinolinyl)oxy]phenyl}-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide AMG-1 |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C31H29FN4O5 |
| Molecular Weight | 556.584 |
| Exact Mass | 556.212219 |
| PSA | 107.61000 |
| LogP | 4.39 |
| Index of Refraction | 1.660 |
| Hazard Codes | Xn |
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