85643-19-2

85643-19-2 structure

Name: Curculigoside
Chemical Name: curculigoside
CAS Number: 85643-19-2
Molecular Formula: C₂₂H₂₆O₁₁
Molecular Weight: 466.435
Catalog: Natural product Phenols
Create Date: 2018-06-25 14:28:30
Modify Date: 2024-01-05 12:08:18
Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway[1].

Name	curculigoside
Synonyms	β-D-Glucopyranoside, 2-(((2,6-dimethoxybenzoyl)oxy)methyl)-4-hydroxyphenyl Curculigoside A 2-(β-D-Glucopyranosyloxy)-5-hydroxybenzyl 2,6-dimethoxybenzoate Benzoic acid, 2,6-dimethoxy-, [2-(β-D-glucopyranosyloxy)-5-hydroxyphenyl]methyl ester

Description	Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Signaling Pathways >> JAK/STAT Signaling >> STAT Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	JAK; STAT; NF-κB[1]
In Vitro	Curculigoside (1-64 μg/ml; 72 hours) exerts significant inhibitory effects on MH7A cell viability between 1 and 64 µg/ml in MH7A cells[1]. Curculigoside (4-16 μg/ml; 24 hours) decreases the protein expression of JAK1, JAK3 and STAT3 compared to the TNF-α group[1]. Cell Viability Assay[1] Cell Line: MH7A cells Concentration: 1 μg/ml; 2 μg/ml; 4 μg/ml; 8 μg/ml; 16 μg/ml; 32 μg/ml; 64 μg/ml Incubation Time: 72 hours Result: Had inhibitory effect on MH7A cells. Western Blot Analysis[1] Cell Line: MH7A cells Concentration: 4 μg/ml; 64 μg/ml Incubation Time: 24 hours Result: Downregulated JAK1, JAK3 and STAT3 protein expression.
References	[1]. Tan S, et al. Curculigoside exerts significant anti arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF κB signaling pathway. Mol Med Rep. 2019 Mar;19(3):2057-2064.

Density	1.5±0.1 g/cm3
Boiling Point	734.9±60.0 °C at 760 mmHg
Melting Point	158-160ºC
Molecular Formula	C₂₂H₂₆O₁₁
Molecular Weight	466.435
Flash Point	253.8±26.4 °C
Exact Mass	466.147522
PSA	164.37000
LogP	-0.02
Vapour Pressure	0.0±2.5 mmHg at 25°C
Index of Refraction	1.624

Safety Phrases	24/25
HS Code	29389090