Name | (+)-usnic acid |
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Synonyms |
Usnic acid
EINECS 231-456-0 (+)-Usniacin (9bR)-2,6-Diacetyl-1,7,9-trihydroxy-8,9b-dimethyldibenzo[b,d]furan-3(9bH)-one 3(9bH)-Dibenzofuranone, 2,6-diacetyl-1,7,9-trihydroxy-8,9b-dimethyl-, (9bR)- MFCD00016878 D-Usnic acid |
Description | (+)-Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+)-Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer activity[1]. |
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Related Catalog | |
Target |
mTORC1 mTORC2 |
References |
Density | 1.5±0.1 g/cm3 |
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Boiling Point | 638.2±55.0 °C at 760 mmHg |
Melting Point | 201-203 °C(lit.) |
Molecular Formula | C18H16O7 |
Molecular Weight | 344.315 |
Flash Point | 236.0±25.0 °C |
Exact Mass | 344.089600 |
PSA | 121.13000 |
LogP | 2.30 |
Vapour Pressure | 0.0±2.0 mmHg at 25°C |
Index of Refraction | 1.679 |
Storage condition | 2~8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H302 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xn |
Risk Phrases | R22 |
Safety Phrases | S36 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
RTECS | HP5295050 |
HS Code | 2917399090 |
HS Code | 2917399090 |
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Summary | 2917399090 aromatic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |