51938-32-0

51938-32-0 structure

Name: Schaftoside
Chemical Name: schaftoside
CAS Number: 51938-32-0
Molecular Formula: C₂₆H₂₈O₁₄
Molecular Weight: 564.49
Catalog: Biochemical Plant extracts
Create Date: 2018-08-31 17:04:29
Modify Date: 2024-01-02 13:10:46
Schaftoside is a flavonoid found in a variety of Chinese herbal medicines, such as Eleusine indica. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission[1].

Name	schaftoside
Synonyms	4H-1-Benzopyran-4-one, 8-(D-arabinopyranosyloxy)-6-(D-glucopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)- Shaftoside Apigenin 8-C-\|A-L-arabinoside 6-C-\|A-D-glucoside Schaftoside 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-8-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]chromen-4-one 8-(D-Arabinopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-6-yl D-glucopyranoside schaftozide

Description	Schaftoside is a flavonoid found in a variety of Chinese herbal medicines, such as Eleusine indica. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Signaling Pathways >> Immunology/Inflammation >> MyD88 Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> Mitochondrial Metabolism Signaling Pathways >> Cytoskeleton >> Dynamin
In Vitro	Schaftoside inhibits three pro-inflammatory enzymatic activities: secretory phospholipase A2 (sPLA2), lipoxygenase (LOX), and cyclooxygenase 2 (COX-2). Schaftoside also inhibits mRNA and protein expressions of proinflammatory cytokines(IL-1β, TNF-α, and IL-6)[1].
References	[1]. Zhou K, et al. Schaftoside ameliorates oxygen glucose deprivation-induced inflammation associated with the TLR4/Myd88/Drp1-related mitochondrial fission in BV2 microglia cells. J Pharmacol Sci. 2019 Jan;139(1):15-22.

Safety Phrases	24/25
RIDADR	NONH for all modes of transport
RTECS	DJ2977250
HS Code	29389090