349087-34-9

349087-34-9 structure

Name: JX-401
Chemical Name: (4-benzylpiperidin-1-yl)-(2-methoxy-4-methylsulfanylphenyl)methanone
CAS Number: 349087-34-9
Molecular Formula: C₂₁H₂₅NO₂S
Molecular Weight: 355.49400
Create Date: 2016-05-03 23:29:49
Modify Date: 2025-08-25 12:14:31
JX401 is a potent inhibitor of p38alpha, containing a 4-benzylpiperidine motif. p38alpha is hyperactive in inflammatory diseases, and various indications suggest that its inhibition would reverse inflammation. JX401 has the potential for the research of inflammation[1].

Name	(4-benzylpiperidin-1-yl)-(2-methoxy-4-methylsulfanylphenyl)methanone
Synonyms	1-[2-Methoxy-4-(methylthio)benzoyl]-4-benzylpiperidine JX401

Description	JX401 is a potent inhibitor of p38alpha, containing a 4-benzylpiperidine motif. p38alpha is hyperactive in inflammatory diseases, and various indications suggest that its inhibition would reverse inflammation. JX401 has the potential for the research of inflammation[1].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology
References	[1]. Friedmann Y, et al. JX401, A p38alpha inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast. Mol Pharmacol. 2006;70(4):1395-1405.