JX-401

Modify Date: 2025-08-25 12:14:31

JX-401 Structure
JX-401 structure
Common Name JX-401
CAS Number 349087-34-9 Molecular Weight 355.49400
Density 1.17g/cm3 Boiling Point 537.3ºC at 760 mmHg
Molecular Formula C21H25NO2S Melting Point N/A
MSDS N/A Flash Point 278.8ºC

 Use of JX-401


JX401 is a potent inhibitor of p38alpha, containing a 4-benzylpiperidine motif. p38alpha is hyperactive in inflammatory diseases, and various indications suggest that its inhibition would reverse inflammation. JX401 has the potential for the research of inflammation[1].

 Names

Name (4-benzylpiperidin-1-yl)-(2-methoxy-4-methylsulfanylphenyl)methanone
Synonym More Synonyms

 JX-401 Biological Activity

Description JX401 is a potent inhibitor of p38alpha, containing a 4-benzylpiperidine motif. p38alpha is hyperactive in inflammatory diseases, and various indications suggest that its inhibition would reverse inflammation. JX401 has the potential for the research of inflammation[1].
Related Catalog
References

[1]. Friedmann Y, et al. JX401, A p38alpha inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast. Mol Pharmacol. 2006;70(4):1395-1405.

 Chemical & Physical Properties

Density 1.17g/cm3
Boiling Point 537.3ºC at 760 mmHg
Molecular Formula C21H25NO2S
Molecular Weight 355.49400
Flash Point 278.8ºC
Exact Mass 355.16100
PSA 54.84000
LogP 4.44990
Index of Refraction 1.611
InChIKey OMGLGPKQUFSRNN-UHFFFAOYSA-N
SMILES COc1cc(SC)ccc1C(=O)N1CCC(Cc2ccccc2)CC1

 Safety Information

Risk Phrases R50/53
Safety Phrases 60-61
RIDADR UN 3077 9/PG 3

 Synonyms

1-[2-Methoxy-4-(methylthio)benzoyl]-4-benzylpiperidine
JX401
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.