Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Triflupromazine hydrochloride
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DC Chemicals Limited
China
Product Name: Siquil
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Siquil
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 10H-Phenothiazine-10-propanamine,N,N-dimethyl-2-(trifluoromethyl)-, hydrochloride (1:1)
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Purity: 98.0%
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1098-60-8

1098-60-8 structure

1098-60-8 structure

Name: Triflupromazine hydrochloride
Chemical Name: triflupromazine hydrochloride
CAS Number: 1098-60-8
Molecular Formula: C₁₈H₂₀ClF₃N₂S
Molecular Weight: 388.878
Catalog: API Nervous system medication Antipsychotic
Create Date: 2018-05-22 08:00:00
Modify Date: 2024-01-04 04:56:26
Triflupromazine hydrochloride is an antipsychotic medication, which are Dopamine D1/D2 receptor antagonists.

Name	triflupromazine hydrochloride
Synonyms	Triflupromazine HCl Fluorofen N,N-Dimethyl-3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]-1-propanamine hydrochloride (1:1) Nivoman Trifluopromazine hydrochloride N,N-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine,hydrochloride flupromazine hydrochloride N,N-Dimethyl-3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propan-1-amine hydrochloride (1:1) 10-[3-(Dimethylamino)propyl]-2-(trifluoromethyl)phenothiazine hydrochloride N,N-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine hydrochloride Phenothiazine, 10-(3-dimethylaminopropyl)-2-(trifluoromethyl)-, hydrochloride Fluopromazinhydrochlorid Vesprin hydrochloride Neoprin Flumazin MFCD00058103 Phenothiazine, 10-[3- (dimethylamino)propyl]-2-(trifluoromethyl)-, monohydrochloride Triflupromazine monohydrochloride EINECS 214-149-6 Triflupromazine hydrochloride 10H-Phenothiazine-10-propanamine, N,N-dimethyl-2-(trifluoromethyl)-, hydrochloride (1:1) triflupromazine

Description	Triflupromazine hydrochloride is an antipsychotic medication, which are Dopamine D1/D2 receptor antagonists.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease

Boiling Point	427.6ºC at 760 mmHg
Melting Point	174.0 to 179.0 °C
Molecular Formula	C₁₈H₂₀ClF₃N₂S
Molecular Weight	388.878
Flash Point	212.4ºC
Exact Mass	388.098785
PSA	31.78000
LogP	6.12680
Vapour Pressure	1.62E-07mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SO8925000

CHEMICAL NAME :: Phenothiazine, 10-(3-(dimethylamino)propyl)-2-(trifluoromethyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 1098-60-8

LAST UPDATED :: 199012

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C18-H19-F3-N2-S.Cl-H

MOLECULAR WEIGHT :: 388.91

WISWESSER LINE NOTATION :: T C666 BN ISJ B3N1&1 EXFFF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 94 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 254 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 102 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 34 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 17 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory obstruction Blood - hemorrhage

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Mammal - species unspecified Kidney

DOSE/DURATION :: 10 mg/L

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 8,617,1970

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301-H312 + H332
Precautionary Statements	Missing Phrase - N15.00950417-P261-P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R20/21/22
Safety Phrases	36
RIDADR	UN 2811 6
WGK Germany	3
RTECS	SO8925000
Packaging Group	III

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