146422-58-4
146422-58-4 structure
- Name: CDD0102
- Chemical Name: 3-ethyl-5-(1,4,5,6-tetrahydropyrimidin-6-yl)-1,2,4-oxadiazole
- CAS Number: 146422-58-4
- Molecular Formula: C8H12N4O
- Molecular Weight: 180.20700
- Catalog: Signaling Pathways GPCR/G Protein mAChR
- Create Date: 2017-07-17 06:47:53
- Modify Date: 2024-01-15 07:00:48
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CDD0102 is a potent M1 Muscarinic receptor agonist.
| Name | 3-ethyl-5-(1,4,5,6-tetrahydropyrimidin-6-yl)-1,2,4-oxadiazole |
|---|---|
| Synonyms |
cdd-102a
unii-9f064nj81d cdd 0102 CDD0102 |
| Description | CDD0102 is a potent M1 Muscarinic receptor agonist. |
|---|---|
| Related Catalog | |
| Target |
mAChR[1] |
| In Vitro | CDD0102 (CDD-0102) is an efficacious muscarinic agonist in cell lines expressing M1 receptors. CDD0102 displays much lower activity at M3 and M5 receptors[1]. |
| In Vivo | After i.p. injections, CDD0102 (CDD-0102) crosses the blood-brain barrier (BBB) in a dose-dependent manner. In toxicological studies, the LD50 of CDD0102 is 190 mg/kg following i.p. injections and greater than 1,000 mg/kg following oral administration. In follow-up studies, after oral administration at a dose of 10 mg/kg, CDD0102 fully reverses memory deficits associated with IgG-192 saporin administration. Again, no side effects are observed at this dose[1]. |
| Cell Assay | A9 L cells expressing muscarinic receptor subtypes are cultured. Biochemical studies examine the ability of compounds (e.g., CDD0102, 0.01 nM, 0.1 nM, 1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 100 μM and 1 mM) to stimulate relevant biochemical responses through muscarinic receptors expressed in A9 Lcells. Assays of PI metabolism provides a measure of in vitro activity associated with M1, M3, and M5 receptor activation, while inhibition of adenylyl cyclase activity determined efficacy at M2 and M4 receptors[1]. |
| Animal Admin | Mice[1] Young, male CF-1 mice are administered CDD0102 or xanomeline by either p.o. or i.p. injection with doses from 1 to 1,000 mg/kg by each route, and monitored for 24 h. Animals are observed daily for 1 wk for appearance of delayed toxicity. A second set of animals is treated with a narrow range of concentrations based on the preliminary studies to determine the LD50. |
| References |
| Molecular Formula | C8H12N4O |
|---|---|
| Molecular Weight | 180.20700 |
| Exact Mass | 180.10100 |
| PSA | 63.31000 |
| LogP | 0.45910 |
| Storage condition | 2-8℃ |