6640-22-8

6640-22-8 structure

Name: Pamoic acid disodium
Chemical Name: disodium,3-carboxy-1-[(3-carboxy-2-oxidonaphthalen-1-yl)methyl]naphthalen-2-olate
CAS Number: 6640-22-8
Molecular Formula: C₂₃H₁₄Na₂O₆
Molecular Weight: 432.333
Catalog: Signaling Pathways MAPK/ERK Pathway ERK
Create Date: 2018-11-26 19:11:01
Modify Date: 2024-01-02 17:32:48
Pamoic acid disodium is a potent GPR35 agonist with an EC50 value of 79 nM. Pamoic acid disodium induces GPR35 internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively. Pamoic acid disodium potently recruits β-arrestin2 to GPR35 and has an antinociceptive effect[1].

Name	disodium,3-carboxy-1-[(3-carboxy-2-oxidonaphthalen-1-yl)methyl]naphthalen-2-olate
Synonyms	Pamoic acid disodium salt embonic acid disodium salt MFCD00036183 pamoate disodique disodium 4,4'-methylene-bis(3-hydroxy-2-naphthoate) dipotassium pamoate(2-) sodium embonate Disodium 4,4'-methylenebis(3-hydroxy-2-naphthoate) Pamoic acid,disodium salt PAMOIC ACID,Na Sodium pamoate disodium 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylate Disodium pamoate disodium 4-[(3-carboxylato-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylate 2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy-, sodium salt (1:2) Disodium methylenebis(2-hydroxy-3-naphthoate) EINECS 229-653-1

Description	Pamoic acid disodium is a potent GPR35 agonist with an EC50 value of 79 nM. Pamoic acid disodium induces GPR35 internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively. Pamoic acid disodium potently recruits β-arrestin2 to GPR35 and has an antinociceptive effect[1].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> ERK Research Areas >> Neurological Disease Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	EC50: 79 nM (GPR35), 65 nM (ERK1/2)[1]
References	[1]. Pingwei Zhao, et al. Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol Pharmacol. 2010 Oct;78(4):560-8.

130-85-8

6640-22-8

Literature: EP626170 A2, ;