2127-03-9

2127-03-9 structure

Name: 2,2′-Dipyridyl disulfide
Chemical Name: 2-(pyridin-2-yldisulfanyl)pyridine
CAS Number: 2127-03-9
Molecular Formula: C₁₀H₈N₂S₂
Molecular Weight: 220.31
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Pyridine derivative
Create Date: 2018-04-10 08:00:00
Modify Date: 2025-08-25 20:36:37
2,2′-Dipyridyl disulfide is a useful reagent for the determination of sulfhydryl groups. 2,2′-Dipyridyl disulfide is a common reagent in peptide chemistry, often used in oxidation–reduction condensations to form peptide bonds or in coupling reactions to form disulfide-linked heterodimers[1].

Name	2-(pyridin-2-yldisulfanyl)pyridine
Synonyms	di(2-pyridyl) disulfide Bis(2-pyridinyl) disulfide 2,2'-Dipyridyl disuldide pyridyl disulfide 2,2'-Dipyridyl disulfide 2-Pyridinyl disulfide 2,2'-DIHYDROXYDIPHENYLMETHANE 2,2'-Dithiobispyridine 1,2-Di(pyridin-2-yl)disulfane 2-Pyridin-2-yldisulfanylpyridine MFCD00006287 EINECS 218-343-1 2,2‘-Dithiodipyridine 2-Dipyridyl disulfide Aldrithiol 2 2,2′-dipyridyldisulfide bis-pyridin-2-yl-disulfide pyridyldisulfide 2,2'-Disulfanediyldipyridine Aldrithiol Bis(2-pyridyl) disulfide 2,2′-dipyridyl disulfide Pyridine, 2,2'-dithiobis- Aldrithiol™-2 2,2'-dipyridinyl disulfide 2,2'-Dithiodipyridine 4,4′-dipyridyldisulfide

Description	2,2′-Dipyridyl disulfide is a useful reagent for the determination of sulfhydryl groups. 2,2′-Dipyridyl disulfide is a common reagent in peptide chemistry, often used in oxidation–reduction condensations to form peptide bonds or in coupling reactions to form disulfide-linked heterodimers[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	Formation of intramolecular S–S bonds can be dramatically accelerated by addition of a 2,2′-Dipyridyl disulfide (2-PDS) solution to an air-oxidized mixture of cysteine-containing peptides[1].
References	[1]. K Maruyama, et al. 2,2'-Bispyridyl disulfide rapidly induces intramolecular disulfide bonds in peptides. Peptides. 1999;20(7):881-4.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R20/22;R37
Safety Phrases	S36/37/39-S37/39-S25-S22
RIDADR	UN3335 9
WGK Germany	3