CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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VZ4800000
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CHEMICAL NAME :
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Sodium chlorite
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CAS REGISTRY NUMBER :
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7758-19-2
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LAST UPDATED :
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199806
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DATA ITEMS CITED :
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28
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MOLECULAR FORMULA :
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Cl-H-O2.Na
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MOLECULAR WEIGHT :
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91.45
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WISWESSER LINE NOTATION :
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.NA..G-O2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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165 mg/kg
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TOXIC EFFECTS :
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Liver - jaundice, other or unclassified Kidney, Ureter, Bladder - interstitial nephritis Biochemical - Metabolism (Intermediary) - other
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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230 mg/m3/4H
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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350 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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300 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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365 mg/kg/1Y-C
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TOXIC EFFECTS :
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Blood - pigmented or nucleated red blood cells Blood - changes in other cell count (unspecified) Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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182 gm/kg/26W-I
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TOXIC EFFECTS :
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Liver - liver function tests impaired Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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29750 mg/kg/85W-C
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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800 mg/kg
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SEX/DURATION :
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female 8-15 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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16 gm/kg
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SEX/DURATION :
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female 8-15 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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660 mg/kg
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SEX/DURATION :
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male 66 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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1130 mg/kg
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SEX/DURATION :
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male 8 week(s) pre-mating female 2 week(s) pre-mating - 3 week(s) post-birth
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - biochemical and metabolic
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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160 mg/kg
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SEX/DURATION :
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female 8-15 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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80 mg/kg
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SEX/DURATION :
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female 8-15 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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22 gm/kg
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SEX/DURATION :
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female 1-21 day(s) after conception lactating female 28 day(s) post-birth
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
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TYPE OF TEST :
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DNA inhibition
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TYPE OF TEST :
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Sperm Morphology
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TYPE OF TEST :
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Micronucleus test
MUTATION DATA
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TYPE OF TEST :
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Cytogenetic analysis
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TEST SYSTEM :
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Rodent - hamster Fibroblast
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DOSE/DURATION :
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20 mg/L
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REFERENCE :
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FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 22,623,1984 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,145,1991 IARC Cancer Review:Human No Available Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,145,1991 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,145,1991 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81982 No. of Facilities: 129 (estimated) No. of Industries: 8 No. of Occupations: 13 No. of Employees: 1968 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81982 No. of Facilities: 532 (estimated) No. of Industries: 20 No. of Occupations: 27 No. of Employees: 18585 (estimated) No. of Female Employees: 4817 (estimated)
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