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1461-15-0

1461-15-0 structure
1461-15-0 structure
  • Name: calcein
  • Chemical Name: calcein
  • CAS Number: 1461-15-0
  • Molecular Formula: C30H26N2O13
  • Molecular Weight: 622.533
  • Catalog: Dye Reagents
  • Create Date: 2018-06-30 17:47:24
  • Modify Date: 2025-08-25 15:33:27
  • Calcein is a fluorescent dye and self-quenching probe, used as an indicator of lipid vesicle leakage, and also as a complexometric indicator for titration of calcium ions with EDTA, and for fluorometric determination of calcium.
Name calcein
Synonyms Fluorescein-bis(methyliminodiacetic acid)
Oftasceinum
Fluorexon
EINECS 215-957-1
Fluorescein complexon
2-[[7'-[[bis(carboxymethyl)amino]methyl]-3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-2'-yl]methyl-(carboxymethyl)amino]acetic acid
2,2',2'',2'''-[(3',6'-Dihydroxy-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-2',7'-diyl)bis(methylenenitrilo)]tetraacetic acid
Bis[N,N−bis(carboxymethyl)aminomethyl]fluorescein
Oftasceina
calcein
2,2',2'',2'''-[(3',6'-dihydroxy-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-2',7'-diyl)bis(methanediylnitrilo)]tetraacetic acid
Oftasceine
MFCD00005049
oftasceinum [INN_la]
Description Calcein is a fluorescent dye and self-quenching probe, used as an indicator of lipid vesicle leakage, and also as a complexometric indicator for titration of calcium ions with EDTA, and for fluorometric determination of calcium.
Related Catalog
In Vitro Calcein accumulates intracellularly in coelomocytes incubated in coelomic fluid or ISO-EDTA. Coelomocytes incubated in CF show an increase in the calcein fluorescence intensity compared to the control.
Cell Assay Coelomocytes suspensions (ISO and CF) are separately incubated with calcein-AM (excitation and emission wavelength: 496 nm and 516 nm, respectively) at a final concentration of 200 nM, during 30 min, at 26°C. Calcein-AM is a nonfluorescent ABC transporter substrate whose intracellular accumulation is inversely proportional to ABC transporter activity. Intracellular esterases convert calcein-AM into the fluorescent dye calcein, which is not an ABC transporter substrate, thereby accumulating the dye inside the cell. Therefore, a high fluorescence signal indicates low ABC transporter activity whereas a low fluorescence signal indicates high activity. The fluorescence of samples is measured by flow cytometer. The experiment is repeated six times in duplicates.
References

[1]. Marques-Santos LF, et al. ABCB1 and ABCC1-like transporters in immune system cells from sea urchins Echinometra lucunter and Echinus esculentus and oysters Crassostrea gasar and Crassostrea gigas. Fish Shellfish Immunol. 2017 Sep 5;70:195-203.
Density 1.7±0.1 g/cm3
Boiling Point 952.7±65.0 °C at 760 mmHg
Melting Point 200 °C
Molecular Formula C30H26N2O13
Molecular Weight 622.533
Flash Point 530.0±34.3 °C
Exact Mass 622.143494
PSA 231.67000
LogP 1.56
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.775
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility insoluble
Hazard Codes Xn:Harmful;
Risk Phrases R20/21/22;R36/37/38
Safety Phrases S22-S24/25-S36/37/39-S26
WGK Germany 3
HS Code 32041900
HS Code 32041900
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