23537-16-8

23537-16-8 structure

Name: Rugulosin((+)-Rugulosin)
Chemical Name: rugulosin
CAS Number: 23537-16-8
Molecular Formula: C₃₀H₂₂O₁₀
Molecular Weight: 542.49000
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2016-05-13 03:45:39
Modify Date: 2024-01-02 21:58:22
Rugulosin is a crystalline colouring matter of Penicillium rugulosum Thom. Rugulosin shows markedly specific antibacterial activity and moderately antifungal activity[1].

Name	rugulosin
Synonyms	(5aS:17S:20S)-1.7.9.15.17.20-hexahydroxy-5.8.13.16-tetraoxo-5.8.13.16-tetrahydro-6H.14H-6c.13ac.!5ar.14c-[1.2.3.4]butanetetrayl-cycloocta[1.2-b:5.6-b']dinaphthalene (+)-Rugulosin,(1S,1S,2R,2R,3S,3S,9aR,9aR)-Rugulosin,(2R,2R)-Rugulosin 5H,6H-6,13A,5A,14-[1,2,3,4]Butanetetraylcycloocta[1,2-B:5,6-B']dinaphthalene-5,8,13,16(14H)-tetrone,1,7,9,15,17,20-hexahydroxy-3,11-dimethyl-,[5as-(5ar,6S,13ar,14S,17R,18S,19S,20R)] (+)-rugulosin (5aS:17S:20S)-1.7.9.15.17.20-Hexahydroxy-5.8.13.16-tetraoxo-5.8.13.16-tetrahydro-6H.14H-6c.13ac.!5ar.14c-[1.2.3.4]butantetryl-cycloocta[1.2-b:5.6-b']dinaphthalin 5H,6H-6,13A,5A,14-[1,2,3,4]Butanetetraylcycloocta[1,2-B:5,6-B']dinaphthalene-5,8,13,16(14H)-tetrone,1,7,9,15,17,20-hexahydroxy-3,11-dimethyl

Description	Rugulosin is a crystalline colouring matter of Penicillium rugulosum Thom. Rugulosin shows markedly specific antibacterial activity and moderately antifungal activity[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Rugulosin is very highly antibacterial active against certain bacilli, streptococci and corynebacteria, but is much less active against Gram-negative organisms[1]. Rugulosin completely inhibits the growth of Pythium intermedium de Bary at a concentration of 1: 50000[1].
References	[1]. BREEN J, et al. Studies in the biochemistry of micro-organisms. 95. Rugulosin, a crystalline colouring matter of Penicillium rugulosum Thom. Biochem J. 1955 Aug;60(4):618-26.

TOXIC EFFECTS :: Behavioral - tremor Behavioral - coma Nutritional and Gross Metabolic - body temperature decrease

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TOXIC EFFECTS :: Behavioral - tremor Behavioral - coma Nutritional and Gross Metabolic - body temperature decrease

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Related to Chronic Data - death

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

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