23537-16-8

• 常用中文名：Rugulosin((+)-Rugulosin)
• 常用英文名：Rugulosin((+)-Rugulosin)
• CAS号：23537-16-8
• 分子式：C₃₀H₂₂O₁₀
• 分子量：542.49000
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2016-05-13 03:45:39
• 更新时间：2024-01-02 21:58:22
• Rugulosin是rugulosum青霉的结晶色素。Rugulosin具有显著的特异性抗菌活性和适度的抗真菌活性[1]。

名称

• 英文名: rugulosin
• 英文别名: (5aS:17S:20S)-1.7.9.15.17.20-hexahydroxy-5.8.13.16-tetraoxo-5.8.13.16-tetrahydro-6H.14H-6c.13ac.!5ar.14c-[1.2.3.4]butanetetrayl-cycloocta[1.2-b:5.6-b']dinaphthalene; (+)-Rugulosin,(1S,1S,2R,2R,3S,3S,9aR,9aR)-Rugulosin,(2R,2R)-Rugulosin; 5H,6H-6,13A,5A,14-[1,2,3,4]Butanetetraylcycloocta[1,2-B:5,6-B']dinaphthalene-5,8,13,16(14H)-tetrone,1,7,9,15,17,20-hexahydroxy-3,11-dimethyl-,[5as-(5ar*,6S*,13ar*,14S*,17R*,18S*,19S*,20R*)]; (+)-rugulosin; (5aS:17S:20S)-1.7.9.15.17.20-Hexahydroxy-5.8.13.16-tetraoxo-5.8.13.16-tetrahydro-6H.14H-6c.13ac.!5ar.14c-[1.2.3.4]butantetryl-cycloocta[1.2-b:5.6-b']dinaphthalin; 5H,6H-6,13A,5A,14-[1,2,3,4]Butanetetraylcycloocta[1,2-B:5,6-B']dinaphthalene-5,8,13,16(14H)-tetrone,1,7,9,15,17,20-hexahydroxy-3,11-dimethyl

物化性质

• 密度: 1.87g/cm3
• 沸点: 980ºC at 760mmHg
• 分子式: C₃₀H₂₂O₁₀
• 分子量: 542.49000
• 闪点: 560.3ºC
• 精确质量: 542.12100
• PSA: 189.66000
• LogP: 2.01080
• 蒸汽压: 0mmHg at 25°C
• 折射率: 1.868
• 储存条件: -20°C，密闭，干燥

生物活性

• 描述: Rugulosin是rugulosum青霉的结晶色素。Rugulosin具有显著的特异性抗菌活性和适度的抗真菌活性[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 真菌
  信号通路 >> 抗感染 >> 细菌
• 体外研究: Rugulosin对某些杆菌、链球菌和棒状杆菌具有很高的抗菌活性,但对革兰氏阴性菌的抗菌活性要低得多[1]。Rugulosin在1:50000的浓度下完全抑制中间腐霉的生长[1]。
• 参考文献:

  [1]. BREEN J, et al. Studies in the biochemistry of micro-organisms. 95. Rugulosin, a crystalline colouring matter of Penicillium rugulosum Thom. Biochem J. 1955 Aug;60(4):618-26.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VM1610000 CHEMICAL NAME : Rugulosin CAS REGISTRY NUMBER : 23537-16-8 LAST UPDATED : 199510 DATA ITEMS CITED : 14 MOLECULAR FORMULA : C30-H22-O10 MOLECULAR WEIGHT : 542.52 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 44 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - coma Nutritional and Gross Metabolic - body temperature decrease TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 55 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - coma Nutritional and Gross Metabolic - body temperature decrease TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1100 mg/kg/22D-C TOXIC EFFECTS : Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Related to Chronic Data - death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4400 mg/kg/1Y-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors MUTATION DATA TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : 100 umol/L REFERENCE : CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 22,2258,1974 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,99,1986 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,99,1986 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW LLOYA2 Lloydia. (Cincinnati, OH) V.1-41, 1938-78. For publisher information, see JNPRDF. Volume(issue)/page/year: 38,21,1975 TOXICOLOGY REVIEW ARMIAZ Annual Review of Microbiology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.1- 1947- Volume(issue)/page/year: 26,279,1972