DC Chemicals Limited
China
Product Name: Hydrocortisone hemisuccinate anhydrous
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Hydrocortisone 21-hemisuccinate
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson
Email: info@tianfuchem.com

2203-97-6

2203-97-6 structure

Name: Hydrocortisone hemisuccinate
Chemical Name: Hydrocortisone 21-hemisuccinate
CAS Number: 2203-97-6
Molecular Formula: C₂₅H₃₄O₈
Molecular Weight: 462.533
Catalog: API Hormone and endocrine-regulating drugs Adrenal corticosteroids
Create Date: 2018-04-04 08:00:00
Modify Date: 2025-08-20 13:57:28
Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a physiological glucocorticoid, and is an orally active steroidal anti-inﬂammatory drug (SAID). Hydrocortisone hemisuccinate inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate can be used for the research of ulcerative colitis (UC)[1][2][3].

Name	Hydrocortisone 21-hemisuccinate
Synonyms	Hydrocortisone 21-he MFCD00046256 saxizon cortisol,hydrogensuccinate cortisolsuccinate Butanedioic acid, mono(11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl) ester hydrocortisone hemisuccinate ester 4-{[(11α)-11,17-Dihydroxy-3,20-dioxopregn-4-en-21-yl]oxy}-4-oxobutanoic acid CORTISOL HEMISUCCINATE Hydrocortisone hydrogen succinate 4-[(11,17-Dihydroxy-3,20-dioxopregn-4-en-21-yl)oxy]-4-oxobutanoic acid Hydrocortisone hemisuccinate EINECS 218-612-3 CORTISOL 21-HEMISUCCINATE hydrocortisone-21-O-hemisuccinate Hydrocortizone Succinate Butanedioic acid, mono[(11α)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl] ester hydrocortisone21-hemisuccinate*freeacid HYDROCORTISONE SUCCINATE

Description	Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a physiological glucocorticoid, and is an orally active steroidal anti-inﬂammatory drug (SAID). Hydrocortisone hemisuccinate inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate can be used for the research of ulcerative colitis (UC)[1][2][3].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor
Target	IL-6:6.7 μM (IC50) IL-3:21.4 μM (IC50)
In Vitro	Hydrocortisone hemisuccinate inhibits IL-6 and IL-3 bioactivity, with IC50s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells[3]. Hydrocortisone hemisuccinate (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures[3].
In Vivo	Hydrocortisone hemisuccinate (30 mg/kg; p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice[2]. Animal Model: Male Sprague-Dawley rats (200-220 g, 10-11 weeks) are induced colitis[2] Dosage: 30 mg/kg Administration: P.o. twice daily for 5 days Result: Significantly decreased the disease activity index (DAI) scores and myeloperoxidase (MPO) activity compared to the 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) group. Increased the body weight.
References	[1]. Kang BS, et, al. Inhibitory effects of anti-inflammatory drugs on interleukin-6 bioactivity. Biol Pharm Bull. 2001 Jun;24(6):701-3. [2]. You YC, et, al. In vitro and in vivo application of pH-sensitive colon-targeting polysaccharide hydrogel used for ulcerative colitis therapy. Carbohydr Polym. 2015 Oct 5;130:243-53. [3]. Langhoff E, et, al. The immunosuppressive potency in vitro of physiological and synthetic steroids on lymphocyte cultures. Int J Immunopharmacol. 1987;9(4):469-73.

Density	1.3±0.1 g/cm3
Boiling Point	685.5±55.0 °C at 760 mmHg
Molecular Formula	C₂₅H₃₄O₈
Molecular Weight	462.533
Flash Point	231.1±25.0 °C
Exact Mass	462.225372
PSA	138.20000
LogP	2.13
Vapour Pressure	0.0±4.8 mmHg at 25°C
Index of Refraction	1.587
Storage condition	−20°C
Water Solubility	Practically insoluble in water, freely soluble in acetone and in anhydrous ethanol. It dissolves in dilute solutions of alkali carbonates and alkali hydroxides.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU5010147

CHEMICAL NAME :: Preg-4-ene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, (11-beta)-

CAS REGISTRY NUMBER :: 2203-97-6

LAST UPDATED :: 199504

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C25-H34-O8

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4200 mg/kg/10W-C

TOXIC EFFECTS :: Immunological Including Allergic - decrease in humoral immune response

REFERENCE :: BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 41,523,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4704 No. of Facilities: 114 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 16945 (estimated) No. of Female Employees: 15681 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TU5010147

108-30-5

50-23-7

~98%

2203-97-6

Literature: Wang, Chao; Zhao, Ming; Qiu, Xuecai; Peng, Shiqi Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 16 p. 4403 - 4421

Precursor 2
108-30-5 50-23-7
DownStream 1
50-23-7

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