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1187-59-3

1187-59-3 structure
1187-59-3 structure
  • Name: N-methylacrylamide
  • Chemical Name: N-methylprop-2-enamide
  • CAS Number: 1187-59-3
  • Molecular Formula: C4H7NO
  • Molecular Weight: 85.104
  • Create Date: 2018-03-29 08:00:00
  • Modify Date: 2024-01-02 00:13:29
Name N-methylprop-2-enamide
Synonyms N-Methyl-2-propenamide
2-Propenamide,N-methyl
N-methylprop-2-enamide
EINECS 214-700-0
(meth-)acrylamide
2-Propenamide, N-methyl-
N-Methyl-acrylamid
N-Methylacrylamide
Acrylamide,N-methyl
Density 0.9±0.1 g/cm3
Boiling Point 207.7±13.0 °C at 760 mmHg
Molecular Formula C4H7NO
Molecular Weight 85.104
Flash Point 103.6±4.8 °C
Exact Mass 85.052765
PSA 29.10000
LogP -0.68
Vapour Pressure 0.2±0.4 mmHg at 25°C
Index of Refraction 1.415
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AS3676000
CHEMICAL NAME :
Acrylamide, N-methyl-
CAS REGISTRY NUMBER :
1187-59-3
BEILSTEIN REFERENCE NO. :
1737696
LAST UPDATED :
199701
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C4-H7-N-O
MOLECULAR WEIGHT :
85.12
WISWESSER LINE NOTATION :
1U1VM1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
476 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
477 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6500 mg/kg/13W-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - structural change in nerve or sheath Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - muscle weakness
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4988 mg/kg/18W-C
TOXIC EFFECTS :
Behavioral - muscle weakness
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2587 mg/kg/8W-I
TOXIC EFFECTS :
Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2544 mg/kg
SEX/DURATION :
male 16 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
595 gm/kg
SEX/DURATION :
male 5 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
595 gm/kg
SEX/DURATION :
male 5 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
596 mg/kg/5W (Continuous)
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 59,201,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1046 No. of Facilities: 122 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 367 (estimated)
Hazard Codes Xi
Risk Phrases R20/21/22
Safety Phrases S23;S26;S36/S37/S39
RIDADR UN 2810
Packaging Group III
Hazard Class 6.1(b)
HS Code 2924199090
7087-68-5 structure

7087-68-5
814-68-6 structure

814-68-6

~%

1187-59-3 structure

1187-59-3
Literature: US5607960 A1, ;
5450-85-1 structure

5450-85-1

~%

1187-59-3 structure

1187-59-3
Literature: Journal of the American Chemical Society, , vol. 71, p. 648,650
814-68-6 structure

814-68-6
74-89-5 structure

74-89-5

~%

1187-59-3 structure

1187-59-3
Literature: US2311548 , ;
6830-81-5 structure

6830-81-5

~%

1187-59-3 structure

1187-59-3
Literature: US2749355 , ;
57-57-8 structure

57-57-8
74-89-5 structure

74-89-5

~%

1187-59-3 structure

1187-59-3
Literature: GB648886 , ;
24685-31-2 structure

24685-31-2

~%

1187-59-3 structure

1187-59-3
Literature: Journal fuer Praktische Chemie (Leipzig), , vol. 318, p. 471 - 478
74-89-5 structure

74-89-5
140-88-5 structure

140-88-5

~%

1187-59-3 structure

1187-59-3
Literature: US2683741 , ;
74-89-5 structure

74-89-5
74-86-2 structure

74-86-2

~%

1187-59-3 structure

1187-59-3
Literature: US2773063 , ;
5450-85-1 structure

5450-85-1

~%

1187-59-3 structure

1187-59-3

75-07-0 structure

75-07-0
64-19-7 structure

64-19-7
Literature: Journal of the American Chemical Society, , vol. 71, p. 648,650
HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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title: CAS No. 1187-59-3 | Chemsrc address: https://www.chemsrc.com/en/baike/243636.html

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