Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Lomefloxacin
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Purity: 98.0%
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Zhejiang Hangyu API Co., Ltd
China
Product Name: Lomefloxacin
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

98079-51-7

98079-51-7 structure

Name: Lomefloxacin
Chemical Name: lomefloxacin
CAS Number: 98079-51-7
Molecular Formula: C₁₇H₁₉F₂N₃O₃
Molecular Weight: 351.348
Catalog: API Synthetic anti-infective drugs Quinolone
Create Date: 2018-07-05 16:44:33
Modify Date: 2024-01-04 13:33:09
Lomefloxacin(SC47111A) is a fluoroquinolone antibiotic.Target: AntibacterialLomefloxacin is a bactericidal fluoroquinolone agent with activity against a wide range of gram-negative and gram-positive organisms. The bactericidal action of lomefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited [1].

Name	lomefloxacin
Synonyms	1-Ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid LFLX Lomefloxacin Lomefloxacinum (±)-1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid 1-Ethyl-6,8-difluoro-7-(3-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid Maxaquin 1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid UNII:L6BR2WJD8V Lomefloxacino 3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo- MFCD00242673 Lomefloxacine

Description	Lomefloxacin(SC47111A) is a fluoroquinolone antibiotic.Target: AntibacterialLomefloxacin is a bactericidal fluoroquinolone agent with activity against a wide range of gram-negative and gram-positive organisms. The bactericidal action of lomefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited [1].
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection
References	[1]. http://www.drugbank.ca/drugs/DB00978

Density	1.3±0.1 g/cm3
Boiling Point	542.7±50.0 °C at 760 mmHg
Melting Point	239-240ºC
Molecular Formula	C₁₇H₁₉F₂N₃O₃
Molecular Weight	351.348
Flash Point	282.0±30.1 °C
Exact Mass	351.139435
PSA	74.57000
LogP	1.71
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.566
Storage condition	−20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VB1997400

CHEMICAL NAME :: 3-Quinolinecarboxylic acid, 1,4-dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-pipera zinyl)-4-oxo-

CAS REGISTRY NUMBER :: 98079-51-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C17-H19-F2-N3-O3

MOLECULAR WEIGHT :: 351.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 24 mg/kg/3D-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3800 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - changes in motor activity (specific assay) Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 698 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 246 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Bacteria - Bacillus subtilis

DOSE/DURATION :: 20 mg/L

REFERENCE :: AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 37,213,1993

Hazard Codes	Xn,Xi
Risk Phrases	22-36/37/38
Safety Phrases	S26-S36
WGK Germany	3
RTECS	VB1997500
HS Code	2933990090

109-07-9

100501-62-0

~93%

98079-51-7

Literature: BERTHON-CEDILLE, Laurence; Leguern, Marie-Emmanuelle; Renaud, Gilles; Tombret, Francis Patent: US2009/54643 A1, 2009 ; Location in patent: Page/Page column 6 ;

75338-42-0

109-07-9

~85%

98079-51-7

Literature: Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154

98079-51-7

Literature: Journal of Chemical Crystallography, , vol. 39, # 5 p. 384 - 388

Precursor 4
109-07-9 100501-62-0 75338-42-0 98079-51-7
DownStream 1
98079-51-7

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

98079-51-7	98079-62-0
114394-67-1	211690-33-4
98079-47-1	98079-52-8
149541-59-3