169815-40-1

169815-40-1 structure

Name: AQ-13 dihydrochloride
Chemical Name: N-(7-chloroquinolin-4-yl)-N',N'-diethylpropane-1,3-diamine,dihydrochloride
CAS Number: 169815-40-1
Molecular Formula: C₁₆H₂₄Cl₃N₃
Molecular Weight: 364.74100
Catalog: Research Areas Infection
Create Date: 2017-10-03 00:32:26
Modify Date: 2024-01-15 18:22:01
AQ-13 dihydrochloride is an aminoquinoline antimalarial drug that is effective against chloroquine-resistant strains of Plasmodium falciparum.

Name	N-(7-chloroquinolin-4-yl)-N',N'-diethylpropane-1,3-diamine,dihydrochloride
Synonyms	AQ 13 1,3-Propanediamine,N'-(7-chloro-4-quinolinyl)-N,N-diethyl-,dihydrochloride (N1-(7-Chloroquinolin-4-yl)-3-(N3,N3-diethylamino)propylamine) dihydrochloride

Description	AQ-13 dihydrochloride is an aminoquinoline antimalarial drug that is effective against chloroquine-resistant strains of Plasmodium falciparum.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Infection
In Vivo	Slight decreases in the PCE/RBC ratio are observed in male and female rats treated with CQ and in females only treated with AQ-13; however, none of these changes is statistically significant[1].
Animal Admin	Rats[1] Male and female Sprague-Dawley rats are used and are 8-9 weeks of age at the time of dose administration. Micronucleus evaluations are conducted in conjunction with repeatdose toxicity studies. Rats are orally administered AQ-13 or CQ in water. Rats are given a “loading dose” followed by maintenance doses of one-half the loading dose administered 12 hr later and daily thereafter for 6 additional days[1].
References	[1]. Riccio ES, et al. Genetic toxicology testing of the antimalarial drugs chloroquine and a new analog, AQ-13. Environ Mol Mutagen. 2001;38(1):69-79.