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China
Product Name: Bromochloroacetonitrile
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83463-62-1

83463-62-1 structure

Name: UNII:SHY3J1BBQ6
Chemical Name: Bromochloroacetonitrile
CAS Number: 83463-62-1
Molecular Formula: C₂HBrClN
Molecular Weight: 154.393
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2018-02-09 08:00:00
Modify Date: 2025-08-20 17:50:15
Bromochloroacetonitrile is a by-product of the chlorine disinfection of water containing natural organic material. Bromochloroacetonitrile possesses direct acting mutagenic activity and is capable of inducing DNA strand breakage[1].

Name	Bromochloroacetonitrile
Synonyms	Acetonitrile, 2-bromo-2-chloro- BROMOCHLOROACETONITRILE Bromo(chloro)acetonitrile UNII:SHY3J1BBQ6 2-bromo-2-chloroacetonitrile

Description	Bromochloroacetonitrile is a by-product of the chlorine disinfection of water containing natural organic material. Bromochloroacetonitrile possesses direct acting mutagenic activity and is capable of inducing DNA strand breakage[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Research Areas >> Others
In Vitro	Bromochloroacetonitrile (BCAN) induces sister chromatid exchange in Chinese hamster ovary cells[1].
References	[1]. Suzanne A. et al.The developmental toxicity of bromochloroacetonitrile in pregnant long‐evans rats, International Journal of Environmental Health Research, 5:2, 175-188.

Density	1.9±0.1 g/cm3
Boiling Point	121.1±20.0 °C at 760 mmHg
Molecular Formula	C₂HBrClN
Molecular Weight	154.393
Flash Point	27.1±21.8 °C
Exact Mass	152.898087
PSA	23.79000
LogP	1.23
Vapour Pressure	14.8±0.2 mmHg at 25°C
Index of Refraction	1.507

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AL8010000

CHEMICAL NAME :: Acetonitrile, bromochloro-

CAS REGISTRY NUMBER :: 83463-62-1

LAST UPDATED :: 199607

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C2-H-Br-Cl-N

MOLECULAR WEIGHT :: 154.40

WISWESSER LINE NOTATION :: NCYGE

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2400 mg/kg/2W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 825 mg/kg

SEX/DURATION :: female 7-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 845 mg/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 585 mg/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 65 mg/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 4200 nmol/L

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 5,1065,1985 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,269,1991 IARC Cancer Review:Human No Available Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,269,1991 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,269,1991

Hazard Codes	Xn
Risk Phrases	R23/24/25;R34
Safety Phrases	S26-S36/37/39-S45
RIDADR	UN 1760
RTECS	AL8010000
Packaging Group	III
Hazard Class	8
HS Code	2926909090

107-14-2

75519-19-6

83463-62-1

144772-39-4

Literature: Water Research, , vol. 33, # 8 p. 1938 - 1948

HS Code	2926909090
Summary	HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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