86811-09-8

86811-09-8 structure

Name: Litoxetine
Chemical Name: 4-(naphthalen-2-ylmethoxy)piperidine
CAS Number: 86811-09-8
Molecular Formula: C₁₆H₁₉NO
Molecular Weight: 241.32800
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-05-22 08:00:00
Modify Date: 2025-09-05 11:38:05
Litoxetine (SL 81.0385) is a selective 5-HT uptake inhibitor. Litoxetine is a 5-HT3 receptor antagonist with a Ki of 85 nM for cerebral 5-HT3 receptors. Litoxetine is an antidepressant and has antiemetic properties[1].

Name	4-(naphthalen-2-ylmethoxy)piperidine
Synonyms	Litoxetinum [INN-Latin] Litoxetina Litoxetine Litoxetinum Litoxetina [INN-Spanish]

Description	Litoxetine (SL 81.0385) is a selective 5-HT uptake inhibitor. Litoxetine is a 5-HT3 receptor antagonist with a Ki of 85 nM for cerebral 5-HT3 receptors. Litoxetine is an antidepressant and has antiemetic properties[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
References	[1]. I Angel, et al. Litoxetine: a selective 5-HT uptake inhibitor with concomitant 5-HT3 receptor antagonist and antiemetic properties. Eur J Pharmacol. 1993 Mar 2;232(2-3):139-45.