2435657-10-4

2435657-10-4 structure

Name: PARP7-IN-16
Chemical Name: PARP7-IN-16
CAS Number: 2435657-10-4
Molecular Formula: C₂₅H₂₆FN₄NaO₄
Molecular Weight: 488.49
Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
Create Date: 2024-01-20 18:50:06
Modify Date: 2024-01-20 18:50:06
PARP7-IN-16 (compound 36) is a potent, selective and orally active inhibitor of PARP-1/2/7, with IC50s of 0.94, 0.87 and 0.21 nM, respectively. PARP7-IN-16 can be used for the research of breast cancer and prostate cancer[1].

Name	PARP7-IN-16

Description	PARP7-IN-16 (compound 36) is a potent, selective and orally active inhibitor of PARP-1/2/7, with IC50s of 0.94, 0.87 and 0.21 nM, respectively. PARP7-IN-16 can be used for the research of breast cancer and prostate cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
Target	PARP-1:0.94 nM (IC50) PARP-2:0.87 nM (IC50) PARP-7:0.21 nM (IC50)
References	[1]. Zhou J, et, al. Discovery of Quinazoline-2,4(1 H,3 H)-dione Derivatives Containing a Piperizinone Moiety as Potent PARP-1/2 Inhibitors─Design, Synthesis, In Vivo Antitumor Activity, and X-ray Crystal Structure Analysis. J Med Chem. 2023 Oct 26;66(20):14095-14115.

Molecular Formula	C₂₅H₂₆FN₄NaO₄
Molecular Weight	488.49