1428439-79-5

1428439-79-5 structure

Name: BChE-IN-20
Chemical Name: BChE-IN-20
CAS Number: 1428439-79-5
Molecular Formula: C₂₇H₃₉N₅O₂
Molecular Weight: 465.63
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2024-02-02 13:06:25
Modify Date: 2024-02-02 13:06:25
BChE-IN-20 (compound 7c) is a highly potent BChE-selective inhibitor and exhibits IC50s of 105 and 2.3 nM for eqBChE and hBChE, respectively. BChE-IN-20 inhibits P glycoprotein with IC50 of 0.27 μM. BChE-IN-20 is a promising template to improve design and development of BChE-selective ligands of pharmaceutical interest, including inhibitors and fluorogenic probes.

Name	BChE-IN-20

Description	BChE-IN-20 (compound 7c) is a highly potent BChE-selective inhibitor and exhibits IC50s of 105 and 2.3 nM for eqBChE and hBChE, respectively. BChE-IN-20 inhibits P glycoprotein with IC50 of 0.27 μM. BChE-IN-20 is a promising template to improve design and development of BChE-selective ligands of pharmaceutical interest, including inhibitors and fluorogenic probes.
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
References	[1]. Modesto de Candia, et al. In-vitro and in-silico studies of annelated 1,4,7,8-tetrahydroazocine ester derivatives as nanomolar selective inhibitors of human butyrylcholinesterase. Chem Biol Interact. 2023 Oct 13:386:110741.

Molecular Formula	C₂₇H₃₉N₅O₂
Molecular Weight	465.63