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9002-01-1

9002-01-1 structure
9002-01-1 structure
  • Name: Streptokinase
  • Chemical Name: 4-cyclohexylpyrrolidine-2-carboxylic acid
  • CAS Number: 9002-01-1
  • Molecular Formula: C11H19NO2
  • Molecular Weight: 197.274
  • Catalog: Biochemical Enzymes and coenzymes
  • Create Date: 2018-08-28 20:32:09
  • Modify Date: 2024-01-04 16:41:01
  • Streptokinase is a bacteria-derived protein and a plasminogen activator. Streptokinase is widely used for the research of the blood-clotting disorders. Streptokinase improves reperfusion blood flow after coronary artery occlusion[1][2].
Name 4-cyclohexylpyrrolidine-2-carboxylic acid
Synonyms L-Proline,4-cyclohexyl-,(4S)
MFCD00082037
Streptokinase
4-Cyclohexylproline
4-cyclohexyl-2-pyrrolidinecarboxylic acid
Proline, 4-cyclohexyl-
Description Streptokinase is a bacteria-derived protein and a plasminogen activator. Streptokinase is widely used for the research of the blood-clotting disorders. Streptokinase improves reperfusion blood flow after coronary artery occlusion[1][2].
Related Catalog
In Vivo Sreptokinase (6000 IU/kg in 3 ml of saline; intracoronary; infused at 0.05 ml/min for 60 minutes beginning 30 minutes before reperfusion) maintains reperfusion coronary blood flow through a critical stenosis at a rate similar to baseline levels[2].
References

[1]. Vaughan DE, et al. Streptokinase-induced platelet aggregation. Prevalence and mechanism. Circulation. 1991;84(1):84-91.

[2]. Mickelson JK, et al. Streptokinase improves reperfusion blood flow after coronary artery occlusion. Int J Cardiol. 1989;23(3):373-384.

Density 1.1±0.1 g/cm3
Boiling Point 343.9±35.0 °C at 760 mmHg
Molecular Formula C11H19NO2
Molecular Weight 197.274
Flash Point 161.8±25.9 °C
Exact Mass 197.141586
PSA 49.33000
LogP 1.99
Appearance lyophilized powder
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.517
Storage condition −20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OB8880000
CHEMICAL NAME :
Kinase (enzyme-activating), strepto-
CAS REGISTRY NUMBER :
9002-01-1
LAST UPDATED :
199512

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Human
DOSE/DURATION :
600 iu/kg
TOXIC EFFECTS :
Immunological Including Allergic - uncharacterized
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 252,1314,1984
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
562500 iu/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 252,1314,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,671,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FOHEAW Folia Haematologica (Leipzig). (Buchexport, Postfach 160, Leipzig DDR-7010, Ger. Dem. Rep.) V.32- 1926- Volume(issue)/page/year: 103,445,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FOHEAW Folia Haematologica (Leipzig). (Buchexport, Postfach 160, Leipzig DDR-7010, Ger. Dem. Rep.) V.32- 1926- Volume(issue)/page/year: 103,445,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,671,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4087 No. of Facilities: 41 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 9366 (estimated) No. of Female Employees: 8266 (estimated)
Hazard Codes C,Xi
Risk Phrases 36/37/38
Safety Phrases 22-24/25-36-26
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS OB8880000

9002-01-1 preparation

9002-01-1 preparation


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