2883653-86-7

2883653-86-7 structure

Name: Helianorphin-19
Chemical Name: Helianorphin-19
CAS Number: 2883653-86-7
Molecular Formula: C₈₁H₁₃₂N₂₆O₁₆S₂
Molecular Weight: 1790.21
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2024-09-16 19:48:47
Modify Date: 2024-09-16 19:48:47
Helianorphin-19 is a potent and selective κ-opioid receptor (KOR) activator with a Ki of 21 nM and an EC50 of 45 nM. Helianorphin-19 exhibits strong KOR-specific peripheral analgesic activity in a mouse model of chronic visceral pain[1].

Name	Helianorphin-19

Description	Helianorphin-19 is a potent and selective κ-opioid receptor (KOR) activator with a Ki of 21 nM and an EC50 of 45 nM. Helianorphin-19 exhibits strong KOR-specific peripheral analgesic activity in a mouse model of chronic visceral pain[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
Target	Ki: 21 nM (KOR) ED50: 45 nM (KOR)[1]
References	[1]. Muratspahić E, et al. Design of a Stable Cyclic Peptide Analgesic Derived from Sunflower Seeds that Targets the κ-Opioid Receptor for the Treatment of Chronic Abdominal Pain. J Med Chem. 2021 Jul 8;64(13):9042-9055.

Molecular Formula	C₈₁H₁₃₂N₂₆O₁₆S₂
Molecular Weight	1790.21