432545-63-6

432545-63-6 structure

Name: Methotrexate-d3
Chemical Name: methotrexate-d3
CAS Number: 432545-63-6
Molecular Formula: C₂₀H₁₉D₃N₈O₅
Molecular Weight: 457.45800
Catalog: analytical chemistry Standard standard material
Create Date: 2016-10-07 19:48:18
Modify Date: 2024-01-05 19:23:24
Methotrexate-d3 (Amethopterin-d3) is the deuterium labeled Methotrexate. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3].

Name	methotrexate-d3

Description	Methotrexate-d3 (Amethopterin-d3) is the deuterium labeled Methotrexate. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Antifolate Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin Research Areas >> Inflammation/Immunology
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Tian H, et al. Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis. Bull NYU Hosp Jt Dis. 2007;65(3):168-73. [3]. Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58(4):473-92. [4]. Ehab Tousson, et al. The Effect of L-carnitine on Amethopterin-induced Toxicity in Rat Large Intestine. [5]. Banji D, et al. Evaluation of the concomitant use of methotrexate and curcumin on Freund's complete adjuvant-induced arthritis and hematological indices in rats. Indian J Pharmacol. 2011;43(5):546-550.

Melting Point	210°C dec.
Molecular Formula	C₂₀H₁₉D₃N₈O₅
Molecular Weight	457.45800
Flash Point	9℃
Exact Mass	457.19000
PSA	210.54000
LogP	1.82170
Storage condition	-20°C Freezer

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310 + P330-P308 + P311-P403 + P233
Hazard Codes	F,T
Risk Phrases	11-23/24/25-39/23/24/25
Safety Phrases	7-16-36/37-45
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution

1664-98-8

54-62-6

432545-63-6

Literature: Elmore, Charles S.; Dean, Dennis C.; Zhang, Yong; Gibson, Carter; Jenkins, Herb; Jones, Allen N.; Melillo, David G. Journal of Labelled Compounds and Radiopharmaceuticals, 2002 , vol. 45, # 1 p. 29 - 36

Precursor 2
1664-98-8 54-62-6
DownStream 1
432545-60-3

432545-63-6	432545-60-3
432545-62-5	1794780-00-9
66147-29-3	34378-65-9
7413-34-5	79640-80-5
50602-77-2	79640-70-3