1498300-35-8

1498300-35-8 structure

Name: TNKS1/2-IN-2
Chemical Name: TNKS1/2-IN-2
CAS Number: 1498300-35-8
Molecular Formula: C₂₆H₂₄F₃N₃O₄
Molecular Weight: 499.48
Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
Create Date: 2023-09-18 15:34:47
Modify Date: 2024-01-17 15:46:10
TNKS1/2-IN-2 (Compound 21) is a potent and selective tankyrases inhibitor. TNKS1/2-IN-2 exhibits IC50 values of 4 nM and 63 nM against TNK1 and TNK2 in the enzymatic assay, respectively. TNKS1/2-IN-2 inhibits proliferation of A549 and H292 cell lines with IC50 values of 39.5 nM and 12.8 nM, respectively. TNKS1/2-IN-2 can be used for the research of cancer[1].

Name	TNKS1/2-IN-2

Description	TNKS1/2-IN-2 (Compound 21) is a potent and selective tankyrases inhibitor. TNKS1/2-IN-2 exhibits IC50 values of 4 nM and 63 nM against TNK1 and TNK2 in the enzymatic assay, respectively. TNKS1/2-IN-2 inhibits proliferation of A549 and H292 cell lines with IC50 values of 39.5 nM and 12.8 nM, respectively. TNKS1/2-IN-2 can be used for the research of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
Target	IC50: 4 nM (TNK1); 63 nM (TNK2); 39.5 nM (A549 cell); 12.8 nM (H292 cell)[1].
References	[1]. Qin D,et al. Discovery of Orally Bioavailable Ligand Efficient Quinazolindiones as Potent and Selective Tankyrases Inhibitors. ACS Med Chem Lett. 2021 May 13;12(6):1005-1010.

Molecular Formula	C₂₆H₂₄F₃N₃O₄
Molecular Weight	499.48