2925298-08-2

2925298-08-2 structure

Name: SB-1436
Chemical Name: SB-1436
CAS Number: 2925298-08-2
Molecular Formula: C₂₅H₂₁ClFNO
Molecular Weight: 405.89
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2023-10-20 18:59:42
Modify Date: 2024-01-30 13:28:21
SB-1436 is an Cholinesterase (ChE) inhibitor, inhibits acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and recombinant human acetylcholinesterase (rHuAChE) with IC50s of 0.176, 0.37 and 0.08 μM, respectively. SB-1436 inhibits AChE and BChE in a non-competitive manner with Kis of 0.046 and 0.115 μM, respectively. SB-1436 significantly stops the self-aggregation of Aβ, and can be used for neurological disease research[1].

Name	SB-1436

Description	SB-1436 is an Cholinesterase (ChE) inhibitor, inhibits acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and recombinant human acetylcholinesterase (rHuAChE) with IC50s of 0.176, 0.37 and 0.08 μM, respectively. SB-1436 inhibits AChE and BChE in a non-competitive manner with Kis of 0.046 and 0.115 μM, respectively. SB-1436 significantly stops the self-aggregation of Aβ, and can be used for neurological disease research[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	EeAChE:0.176 μM (IC50) eqBCHE:0.37 μM (IC50) EeAChE:0.046 μM (Ki) eqBCHE:0.115 μM (Ki)
References	[1]. Abdullaha M, et.al. Methoxy-naphthyl-Linked N-Benzyl Pyridinium Styryls as Dual Cholinesterase Inhibitors: Design, Synthesis, Biological Evaluation, and Structure-Activity Relationship. ACS Omega. 2023 May 9;8(20):17591-17608.

Molecular Formula	C₂₅H₂₁ClFNO
Molecular Weight	405.89