2425632-57-9

2425632-57-9 structure

Name: BChE-IN-17
Chemical Name: BChE-IN-17
CAS Number: 2425632-57-9
Molecular Formula: C₂₃H₂₃BrN₂O₄S₂
Molecular Weight: 535.47
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2023-09-30 19:07:03
Modify Date: 2024-11-29 17:45:07
BChE-IN-17 (compound 6n) is a potent and selective BChE inhibitor with IC50s of 10.5 nM and 32.5 nM for eqBChE and hBChE, respectively. BChE-IN-17 shows over 1000-fold selectivity to BChE against AChE. BChE-IN-17 shows low neurotoxicity and moderate neuroprotective effects[1].

Name	BChE-IN-17

Description	BChE-IN-17 (compound 6n) is a potent and selective BChE inhibitor with IC50s of 10.5 nM and 32.5 nM for eqBChE and hBChE, respectively. BChE-IN-17 shows over 1000-fold selectivity to BChE against AChE. BChE-IN-17 shows low neurotoxicity and moderate neuroprotective effects[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	eqBCHE:10.5 nM (IC50) hBCHE:32.5 nM (IC50) eel AChE:686.4 μM (IC50)
References	[1]. Tingkai Chen, et al. The structural modification and biological evaluation of tetrahydrothienopyridine derivatives as selective BChE inhibitors. Bioorg Med Chem Lett. 2023 Sep 1;93:129436.

Molecular Formula	C₂₃H₂₃BrN₂O₄S₂
Molecular Weight	535.47