846569-60-6

846569-60-6 structure

Name: AP102
Chemical Name: AP102
CAS Number: 846569-60-6
Molecular Formula: C₅₀H₆₆I₂N₁₂O₁₀S₂
Molecular Weight: 1313.07
Catalog: Signaling Pathways GPCR/G Protein Somatostatin Receptor
Create Date: 2023-10-18 09:14:35
Modify Date: 2024-01-12 16:55:53
AP102 is a dual SSTR2/SSTR5-specific somatostatin analog (SSA). AP102 is a disulfide-bridged octapeptide SSA containing synthetic iodinated amino acids. AP102 binds with subnanomolar affinity to SSTR2 and SSTR5 (IC50: 0.63 and 0.65 nM, respectively). AP102 does not bind to SSTR1 or SSTR3. AP102 can be used for acromegaly and neuroendocrine tumors research[1].

Name	AP102

Description	AP102 is a dual SSTR2/SSTR5-specific somatostatin analog (SSA). AP102 is a disulfide-bridged octapeptide SSA containing synthetic iodinated amino acids. AP102 binds with subnanomolar affinity to SSTR2 and SSTR5 (IC50: 0.63 and 0.65 nM, respectively). AP102 does not bind to SSTR1 or SSTR3. AP102 can be used for acromegaly and neuroendocrine tumors research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor Research Areas >> Metabolic Disease Research Areas >> Neurological Disease
Target	SSTR2:0.63 nM (IC50) SSTR5:0.65 nM (IC50)
References	[1]. Tarasco E, et al. Effect of AP102, a subtype 2 and 5 specific somatostatin analog, on glucose metabolism in rats. Endocrine. 2017 Oct;58(1):124-133.

Molecular Formula	C₅₀H₆₆I₂N₁₂O₁₀S₂
Molecular Weight	1313.07