312281-74-6

312281-74-6 structure

Name: BPDBA
Chemical Name: BPDBA
CAS Number: 312281-74-6
Molecular Formula: C₁₉H₂₀Cl₂N₂O
Molecular Weight: 363.28
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2023-06-04 15:19:47
Modify Date: 2024-01-10 19:39:58
BPDBA is a selective and noncompetitive betaine/GABA transporter (BGT-1) inhibitor with IC50s of 20 μM and 35 μM against human BGT-1 and mouse GAT2, respectively[1].

Name	BPDBA
Synonyms	N-(1-benzylpiperidin-4-yl)-2,4-dichlorobenzamide

Description	BPDBA is a selective and noncompetitive betaine/GABA transporter (BGT-1) inhibitor with IC50s of 20 μM and 35 μM against human BGT-1 and mouse GAT2, respectively[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vivo	BPDBA 被预测具有良好的口服吸收和血脑屏障穿透性能[1]。
References	[1]. Kragholm B, et al. Discovery of a subtype selective inhibitor of the human betaine/GABA transporter 1 (BGT-1) with a non-competitive pharmacological profile. Biochem Pharmacol. 2013 Aug 15;86(4):521-8.