2377239-85-3
2377239-85-3 structure
- Name: IOX2 sodium
- Chemical Name: IOX2 sodium
- CAS Number: 2377239-85-3
- Molecular Formula: C19H15N2NaO5
- Molecular Weight: 374.32
- Catalog: Signaling Pathways Metabolic Enzyme/Protease HIF/HIF Prolyl-Hydroxylase
- Create Date: 2023-05-31 10:21:37
- Modify Date: 2025-08-25 09:50:30
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IOX2 sodium is a specific prolyl hydroxylase-2 (PHD2) inhibitor with IC50 of 22 nM. IOX2 sodium regulates platelet function and arterial thrombosis by upregulating HIF-1α expression and inhibiting ROS production. IOX2 sodium can be used in the study of thrombotic diseases[1][2].
| Name | IOX2 sodium |
|---|
| Description | IOX2 sodium is a specific prolyl hydroxylase-2 (PHD2) inhibitor with IC50 of 22 nM. IOX2 sodium regulates platelet function and arterial thrombosis by upregulating HIF-1α expression and inhibiting ROS production. IOX2 sodium can be used in the study of thrombotic diseases[1][2]. |
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| Related Catalog | |
| Target |
IC50: 22 nM (PHD2)[2] |
| In Vitro | IOX2 sodium (0、10、25 和 50 μM) 剂量依赖性地抑制胶原蛋白相关肽 (CRP；0.25μg/mL) 或凝血酶 (0.03 U/mL) 诱导的血小板聚集和 ATP 释放。 但 IOX2 不影响 P-选择素表达和糖蛋白 (GP)Ibα、GPVI 或 αIIbβ3 的表面水平[1]。 IOX2 sodium 还抑制血小板在纤维蛋白原或胶原蛋白上的扩散和凝块回缩[1]。 IOX2 sodium (50 μM；24 h) 增加正常人的表皮角质形成细胞 (NHEK) 和正常人真皮成纤维细胞 (NHDF) 在常氧和缺氧条件下生长时 VEGF-A 和 BNIP3 的转录水平[2]。 |
| In Vivo | IOX2 sodium (10 mg/kg；腹腔注射；单剂量) 损害小鼠体内血小板的止血功能和动脉血栓形成[1]。 Animal Model: Mouse[1] Dosage: 10 mg/kg Administration: Intraperitoneal injection Result: Upregulated HIF-1α in platelets, decreased ROS generation, and downregulated NOX1 expression. Increased the phosphorylation level of VASP (Ser157/239), and inhibited the phosphorylation of p38 (Thr180/Tyr182), ERK1/2 (Thr202/Tyr204), AKT (Thr308/Ser473), and PKCδ (Thr505) in CRP- or thrombin-stimulated platelets. |
| References |
| Molecular Formula | C19H15N2NaO5 |
|---|---|
| Molecular Weight | 374.32 |