2225800-19-9

2225800-19-9 structure

Name: PARP10-IN-3
Chemical Name: PARP10-IN-3
CAS Number: 2225800-19-9
Molecular Formula: C₁₄H₁₂N₂O₃
Molecular Weight: 256.26
Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
Create Date: 2023-04-05 19:54:10
Modify Date: 2024-04-05 22:00:08
PARP10-IN-3 is a selective mono‐ADP‐ribosyltransferase PARP10 inhibitor with an IC50 of 480 nM for human PARP10. PARP10-IN-3 reveals potent inhibition on PARP2 and PARP15 with IC50s of 1.7 μM for human PARP2 and human PARP15, respectively[1].

Name	PARP10-IN-3

Description	PARP10-IN-3 is a selective mono‐ADP‐ribosyltransferase PARP10 inhibitor with an IC50 of 480 nM for human PARP10. PARP10-IN-3 reveals potent inhibition on PARP2 and PARP15 with IC50s of 1.7 μM for human PARP2 and human PARP15, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
Target	human PARP10:480 nM (IC50) human PARP2:1.7 μM (IC50) human PARP15:1.7 μM (IC50) human TNKS2:6.5 μM (IC50) human PARP4:7 μM (IC50) human TNKS1:21 μM (IC50) human PARP14:41 μM (IC50) human PARP12:>10 μM (IC50) human PARP16:>10 μM (IC50) human PARP1:>100 μM (IC50) human PARP3:>100 μM (IC50)
In Vitro	PARP10-IN-3 (化合物 20) 在 HeLa-PARP10 细胞中通过克隆形成测定 (CFA) 的 IC50 为 1-2 μM[1]。
References	[1]. Patricia Korn, et al. Evaluation of 3- and 4-Phenoxybenzamides as Selective Inhibitors of the Mono-ADP-Ribosyltransferase PARP10. ChemistryOpen. 2021 Oct;10(10):939-948.