909207-35-8
909207-35-8 structure
- Name: ISX-1
- Chemical Name: ISX-1
- CAS Number: 909207-35-8
- Molecular Formula: C14H14N4O2S
- Molecular Weight: 302.35
- Catalog: Research Areas Others
- Create Date: 2023-05-11 11:20:42
- Modify Date: 2024-04-10 22:29:25
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ISX-1 is an isoxazole. ISX-1 has anti-adipogenic and pro-osteogenic activities. ISX-1 can be used for the research of osteopenia and osteoporosis[1].
| Name | ISX-1 |
|---|
| Description | ISX-1 is an isoxazole. ISX-1 has anti-adipogenic and pro-osteogenic activities. ISX-1 can be used for the research of osteopenia and osteoporosis[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 1.9 μM (lipid droplet formation); EC50: 1.2 μM (induce ALP)[1] |
| In Vitro | ISX-1 剂量依赖性地抑制细胞内脂滴的积累并刺激 ALP 活性[1]。 ISX-1 可形成脂滴，IC50 值为 1.9 μM，也可诱导 ALP，EC50 值为 1.2 μM[1]。 ISX-1（0、1.3、6.5 和 33 μM；3 天）抑制 hBMSCs 成脂分化过程中 PPARγ 和 FABP4 基因的 mRNA 诱导[1]。 ISX-1（0、1.3、6.5 和 33 μM）促进 TCF/LEF 介导的基因转录[1]。 RT-PCR[1] Cell Line: Human bone marrow mesenchymal stem cells (hBMSCs) Concentration: 0, 1.3, 6.5 and 33 μM Incubation Time: 3 days Result: Inhibited the mRNA induction of PPARγ and FABP4 genes under the adipogenic differentiation of hBMSCs and showed no effect on C/EBPα expression. Western Blot Analysis[1] Cell Line: HEK 293 cells Concentration: 6.5 and 33 μM Incubation Time: 6.5 and 33 μM Result: Increased both the amount of activated and total β-catenin. |
| References |
| Molecular Formula | C14H14N4O2S |
|---|---|
| Molecular Weight | 302.35 |