2387505-47-5
2387505-47-5 structure
- Name: MRS2279 diammonium
- Chemical Name: MRS2279 diammonium
- CAS Number: 2387505-47-5
- Molecular Formula: C13H24ClN7O8P2
- Molecular Weight: 503.77
- Catalog: Signaling Pathways GPCR/G Protein P2Y Receptor
- Create Date: 2022-11-27 11:39:03
- Modify Date: 2024-02-03 10:52:43
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MRS2279 diammonium is a selective and high affinity P2Y1 receptor antagonist, with a Ki value of 2.5 nM and an IC50 value of 51.6 nM. MRS2279 diammonium competitively inhibits ADP-promoted platelet aggregation with an pKb value of 8.05[1][2][3].
| Name | MRS2279 diammonium |
|---|
| Description | MRS2279 diammonium is a selective and high affinity P2Y1 receptor antagonist, with a Ki value of 2.5 nM and an IC50 value of 51.6 nM. MRS2279 diammonium competitively inhibits ADP-promoted platelet aggregation with an pKb value of 8.05[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
P2Y1 Receptor:51.6 nM (IC50) |
| In Vitro | MRS2279 diammonium antagonizes 2-MeSADP-stimulated inositol phosphate formation in turkey erythrocyte membranes with a pKb value of 7.75[2]. MRS2279 diammonium shows high affinity competitive antagonism to human P2Y1 receptor with a pKb value of 8.10 in 1321N1 human astrocytoma cells[2]. MRS2279 diammonium shows specific effect for the P2Y1 receptor, but shows no effect on activation of the human P2Y2, P2Y4, P2Y6, or P2Y11 receptors by their cognate agonists[2]. MRS2279 diammonium shows no ability to block the capacity of ADP to act through the Gi/adenylyl cyclase linked P2Y receptor of platelets to inhibit cyclic AMP accumulation[2]. |
| In Vivo | MRS2279 diammonium (2 μL, 1 nM; intracerebroventricular injection; 30 min prior to mechanical ventilation) reduces mouse brain injury induced by mechanical ventilation in high-pressure ventilation mice[3]. |
| Molecular Formula | C13H24ClN7O8P2 |
|---|---|
| Molecular Weight | 503.77 |