438474-67-0
438474-67-0 structure
- Name: Antitrypanosomal agent 9
- Chemical Name: WAY-325462
- CAS Number: 438474-67-0
- Molecular Formula: C22H27NO3
- Molecular Weight: 353.45
- Catalog: Research Areas Infection
- Create Date: 2022-11-28 19:47:51
- Modify Date: 2024-04-03 15:53:49
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Antitrypanosomal agent 9 (compound 1) is a potent antitrypanosomal agent. Antitrypanosomal agent 9 shows inhibitory activity against T. b. brucei, with an IC50 of 1.15 μM. Antitrypanosomal agent 9 can be used for human African trypanosomiasis (HAT) research[1].
| Name | WAY-325462 |
|---|---|
| Synonyms |
Methanone, [4-[(4-ethoxyphenoxy)methyl]phenyl](3-methyl-1-piperidinyl)-
{4-[(4-Ethoxyphenoxy)methyl]phenyl}(3-methyl-1-piperidinyl)methanone |
| Description | Antitrypanosomal agent 9 (compound 1) is a potent antitrypanosomal agent. Antitrypanosomal agent 9 shows inhibitory activity against T. b. brucei, with an IC50 of 1.15 μM. Antitrypanosomal agent 9 can be used for human African trypanosomiasis (HAT) research[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Antitrypanosomal agent 9 (compound 1) shows inhibitory activity against T. b. rhodesiense, T. cruzi, L. donovani, and P. falciparum, with IC50 values of 0.985 ± 0.076, 107 ± 34.5, 35.7 ± 6.22, and 22.3 ± 1.06 μM, respectively[1]. Antitrypanosomal agent 9 shows cytotoxicity in L6 cells, with an IC50 of 186 ± 94.2 μM[1]. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 521.5±35.0 °C at 760 mmHg |
| Molecular Formula | C22H27NO3 |
| Molecular Weight | 353.45 |
| Flash Point | 269.2±25.9 °C |
| Exact Mass | 353.199097 |
| LogP | 4.00 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.560 |