Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-Propanone,1-(3,4-dichlorophenyl)-3-(dimethylamino)-, hydrochloride (1:1)
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

75144-12-6

75144-12-6 structure

Name: Antitrypanosomal agent 1
Chemical Name: 1-(3,4-dichlorophenyl)-3-(dimethylamino)propan-1-one,hydrochloride
CAS Number: 75144-12-6
Molecular Formula: C₁₁H₁₄Cl₃NO
Molecular Weight: 282.59400
Catalog: Research Areas Infection
Create Date: 2018-12-03 19:02:53
Modify Date: 2024-01-13 17:48:20
Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor with an IC50 of 3.3 μM. Antitrypanosomal agent 1 inhibits glutathione reductase (GR) (IC50=64.8 μM) and T. brucei (EC50=1 μM). Antitrypanosomal agent 1 has anti-trypanosomal activity[1].

Name	1-(3,4-dichlorophenyl)-3-(dimethylamino)propan-1-one,hydrochloride
Synonyms	1-(3,4-Dichlorophenyl)-3-dimethylamino-1-propanone HCl AmbscPOD_38/0850 1-(3,4-dichlorophenyl)-3-dimethylamino-1-propanone hydrochloride

Description	Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor with an IC50 of 3.3 μM. Antitrypanosomal agent 1 inhibits glutathione reductase (GR) (IC50=64.8 μM) and T. brucei (EC50=1 μM). Antitrypanosomal agent 1 has anti-trypanosomal activity[1].
Related Catalog	Research Areas >> Infection
Target	IC50: 3.3 μM (trypanothione reductase) and 64.8 μM (glutathione reductase)[1] EC50: 1 μM (T. brucei)[1]
In Vitro	Antitrypanosomal agent 1 (compound 8a) has an selectivity for TR (GR IC50/TR IC50) of 20[1].
References	[1]. Martyn DC, et al. High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1280-3.

Density	1.22g/cm3
Boiling Point	341.9ºC at 760 mmHg
Molecular Formula	C₁₁H₁₄Cl₃NO
Molecular Weight	282.59400
Flash Point	160.6ºC
Exact Mass	281.01400
PSA	20.31000
LogP	3.92980
Index of Refraction	1.544
Storage condition	2-8℃

35857-66-0

124-40-3

~84%

75144-12-6

Literature: Shanghai Institute of Pharmaceutical Industry; Li, Jianqi; Zheng, Yongyong; Liao, Yunfeng; Li, Yali Patent: US2013/72488 A1, 2013 ; Location in patent: Paragraph 0165 ;

50-00-0

506-59-2

2642-63-9

~49%

75144-12-6

Literature: Du, Xiaohui; Guo, Chun; Hansell, Elizabeth; Doyle, Patricia S.; Caffrey, Conor R.; Holler, Tod P.; McKerrow, James H.; Cohen, Fred E. Journal of Medicinal Chemistry, 2002 , vol. 45, # 13 p. 2695 - 2707

95-50-1

75144-12-6

Literature: Shanghai Institute of Pharmaceutical Industry; Li, Jianqi; Zheng, Yongyong; Liao, Yunfeng; Li, Yali Patent: US2013/72488 A1, 2013 ;

Precursor 6
35857-66-0 124-40-3 50-00-0 506-59-2
2642-63-9 95-50-1
DownStream 1
50516-63-7

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