2492436-38-9

2492436-38-9 structure

Name: Antitrypanosomal agent 7
Chemical Name: Antitrypanosomal agent 7
CAS Number: 2492436-38-9
Molecular Formula: C₂₃H₃₁Cl₂N₅O₂
Molecular Weight: 480.43
Catalog: Research Areas Infection
Create Date: 2022-07-01 20:28:33
Modify Date: 2024-04-05 22:38:58
Antitrypanosomal agent 7 (compound 18c) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 7 is > 2-fold more potent against Trypanosoma brucei (T. brucei) than Nifurtimox, with an IC50 value of 0.71 μM. Antitrypanosomal agent 7 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA[1].

Name	Antitrypanosomal agent 7

Description	Antitrypanosomal agent 7 (compound 18c) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 7 is > 2-fold more potent against Trypanosoma brucei (T. brucei) than Nifurtimox, with an IC50 value of 0.71 μM. Antitrypanosomal agent 7 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA[1].
Related Catalog	Research Areas >> Infection
Target	IC50: 0.71 μM (T. brucei)[1]
References	[1]. Popov AB,et al. DNA/RNA binding and in vitro ADME profiling of novel imidazoline-substituted 2-arylbenzimidazoles. Eur J Med Chem. 2020 Dec 1;207:112802.

Molecular Formula	C₂₃H₃₁Cl₂N₅O₂
Molecular Weight	480.43