2322245-42-9
2322245-42-9 structure
- Name: SRI-37330
- Chemical Name: Methanesulfonamide, N-[[1-[6-(trifluoromethyl)-4-quinazolinyl]-3-piperidinyl]methyl]-
- CAS Number: 2322245-42-9
- Molecular Formula: C16H19F3N4O2S
- Molecular Weight: 388.41
- Catalog: Research Areas Metabolic Disease
- Create Date: 2022-11-01 18:02:43
- Modify Date: 2025-08-25 11:49:29
-
SRI-37330 is an orally active TXNIP inhibitor. SRI-37330 decreases glucagon secretion and action and blocks hepatic glucose output. SRI-37330 can be used in the research of obesity and diabetes[1].
| Name | Methanesulfonamide, N-[[1-[6-(trifluoromethyl)-4-quinazolinyl]-3-piperidinyl]methyl]- |
|---|
| Description | SRI-37330 is an orally active TXNIP inhibitor. SRI-37330 decreases glucagon secretion and action and blocks hepatic glucose output. SRI-37330 can be used in the research of obesity and diabetes[1]. |
|---|---|
| Related Catalog | |
| Target |
TXNIP[1] |
| In Vitro | SRI-37330 (1 μM, 24 h) inhibits the activity of the human TXNIP promoter in INS-1 cells[1]. SRI-37330 (1 μM, 24 h) inhibits Mrna and protein levels of TXNIP in INS-1 cells[1]. SRI-37330 (5 μM, 24 h) inhibits polymerase II (Pol II) binding to the E-box motif region of the TXNIP promoter[1]. SRI-37330 (5 μM, 24 h) lowers glucagon secretion in TC1-6 cells[1]. SRI-37330 (0-5 μM, 24 h) inhibits glucagon-induced glucose output from primary hepatocytes[1]. RT-PCR[1] Cell Line: INS-1 cells Concentration: 1 μM Incubation Time: 24 h Result: Inhibited endogenous TXNIP mRNA expression with an IC50 of 0.64 μM. |
| In Vivo | SRI-37330 (100 mg/kg, p.o., in drinking water, 3 weeks) decreases glucagon secretion and action and blocks hepatic glucose output[1]. SRI-37330 (100 mg/kg, p.o., in drinking water, 3 weeks) is well tolerated in male C57BL/6J mice[1]. SRI-37330 (100 mg/kg, p.o., in drinking water, 3 weeks) reverses obesity- and STZ-induced diabetes and hepatic steatosis in mice[1]. Animal Model: C57BL/6J mice[1] Dosage: 100 mg/kg Administration: Oral administration (p.o.), in drinking water, 3 weeks. Result: Lowered serum glucagon levels, inhibited hepatic glucose production and improved glucose homeostasis in mice. |
| Molecular Formula | C16H19F3N4O2S |
|---|---|
| Molecular Weight | 388.41 |