1021238-13-0

1021238-13-0 structure

1021238-13-0 structure

Name: MAO-B-IN-16
Chemical Name: MAO-B-IN-16
CAS Number: 1021238-13-0
Molecular Formula: C₁₈H₁₉NO₃
Molecular Weight: 297.35
Catalog: Signaling Pathways Neuronal Signaling Monoamine Oxidase
Create Date: 2022-10-31 17:05:16
Modify Date: 2024-01-05 19:44:48
MAO-B-IN-16 is a selective monoamine oxidase B (MAO-B) inhibitor, with an IC50 of 1.55 µM. MAO-B-IN-16 can be used in the study of central nervous disorders, such as parkinson's disease[1].

Name	MAO-B-IN-16

Description	MAO-B-IN-16 is a selective monoamine oxidase B (MAO-B) inhibitor, with an IC50 of 1.55 µM. MAO-B-IN-16 can be used in the study of central nervous disorders, such as parkinson's disease[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease
Target	hMAO-B:1.55 μM (IC50) hMAO-A:＞100 μM (IC50)
In Vitro	MAO-B-IN-16 (compound 4h) (10 μM; 24 h) has no cytotoxic effect on human neuroblastoma cells[1]. Cell Viability Assay[1] Cell Line: SH-SY5Y cells Concentration: 10 μM Incubation Time: 24 h Result: Showed no cytotoxic effect on cells with cellular viability of 99%.
References	[1]. Yamada M, et al. Design, Synthesis, and Monoamine Oxidase B Selective Inhibitory Activity of N-Arylated Heliamine Analogues. ACS Medicinal Chemistry Letters, 2022.

Molecular Formula	C₁₈H₁₉NO₃
Molecular Weight	297.35