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2657-25-2

2657-25-2 structure
2657-25-2 structure
  • Name: 2-Benzal-4-hydroxyacetophenone
  • Chemical Name: 4'-hydroxychalcone
  • CAS Number: 2657-25-2
  • Molecular Formula: C15H12O2
  • Molecular Weight: 224.25500
  • Catalog: Biochemical Plant extracts
  • Create Date: 2018-03-12 08:00:00
  • Modify Date: 2025-08-21 16:47:12
  • 4'-Hydroxychalcone, a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria[1][2][3].
Name 4'-hydroxychalcone
Synonyms MFCD00016484
2-BENZAL-4'-HYDROXYACETOPHENONE
BENZYLIDENE-4'-HYDROXYACETOPHENONE
4'-HYDROXYCHALCONE
HYDROXYCHALCONE,4'
4′-Hydroxychalcone
1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one
2-Benzylidene-4'-hydroxyacetophenone
Description 4'-Hydroxychalcone, a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria[1][2][3].
Related Catalog
References

[1]. Inoue B, et al. The effects of echinatin and its related compounds on the mitochondrial energy transfer reaction. J Toxicol Sci. 1982 Nov;7(4):245-54.

[2]. Ali Reza, et al. Hepatoprotective activity of phloretin and hydroxychalcones against Acetaminophen Induced hepatotoxicity in mice. Iranian Journal of Pharmaceutical Sciences. 2011 Jan; 7(2).

[3]. Orlikova B, et al. The aromatic ketone 4'-hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. Biochem Pharmacol. 2011 Sep 15;82(6):620-31.
Density 1.191 g/cm3
Boiling Point 419.6ºC at 760 mmHg
Melting Point 174-178 °C
Molecular Formula C15H12O2
Molecular Weight 224.25500
Flash Point 179.1ºC
Exact Mass 224.08400
PSA 37.30000
LogP 3.28830
Vapour Pressure 1.23E-07mmHg at 25°C
Index of Refraction 1.653
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S37/39-S26
100-52-7 structure

100-52-7

99-93-4 structure

99-93-4

~98%

2657-25-2 structure

2657-25-2

Literature: Rafiee, Ezzat; Rahimi, Farzaneh Monatshefte fur Chemie, 2013 , vol. 144, # 3 p. 361 - 367
22966-19-4 structure

22966-19-4

~99%

2657-25-2 structure

2657-25-2

Literature: Gavande, Navnath S.; Kundu, Sonia; Badgujar, Naresh S.; Kaur, Gurmeet; Chakraborti, Asit K. Tetrahedron, 2006 , vol. 62, # 17 p. 4201 - 4204
99-93-4 structure

99-93-4

~%

2657-25-2 structure

2657-25-2

Literature: Manna, Fedele; Chimenti, Franco; Fioravanti, Rossella; Bolasco, Adriana; Secci, Daniela; Chimenti, Paola; Ferlini, Cristiano; Scambia, Giovanni Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 20 p. 4632 - 4635
468060-22-2 structure

468060-22-2

~16%

2657-25-2 structure

2657-25-2

Literature: Liu; Wilairat; Go Journal of Medicinal Chemistry, 2001 , vol. 44, # 25 p. 4443 - 4452
16162-69-9 structure

16162-69-9

100-52-7 structure

100-52-7

~84%

2657-25-2 structure

2657-25-2

Literature: Lin, Chun-Nan; Lee, Tai-Hua; Hsu, Mei-Feng; Wang, Jih-Pyang; Ko, Feng-Nien; Teng, Che-Ming Journal of Pharmacy and Pharmacology, 1997 , vol. 49, # 5 p. 530 - 536
16162-69-9 structure

16162-69-9

~%

2657-25-2 structure

2657-25-2

Literature: Sogawa; Nihro; Ueda; Izumi; Miki; Matsumoto; Satoh Journal of Medicinal Chemistry, 1993 , vol. 36, # 24 p. 3904 - 3909
140-10-3 structure

140-10-3

108-95-2 structure

108-95-2

~%

2657-25-2 structure

2657-25-2

Literature: Nakazawa et al. Yakugaku Zasshi, 1954 , vol. 74, p. 495 Chem.Abstr., 1955 , p. 8182
2757-04-2 structure

2757-04-2

~%

888-12-0 structure

888-12-0

2657-25-2 structure

2657-25-2

Literature: Singh, A.K.; Raghuraman, T.S. Tetrahedron Letters, 1985 , vol. 26, # 34 p. 4125 - 4128
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