156765-33-2

156765-33-2 structure

Name: Aviculin
Chemical Name: Aviculin
CAS Number: 156765-33-2
Molecular Formula: C₂₆H₃₄O₁₀
Molecular Weight: 506.54
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-09-01 16:30:22
Modify Date: 2023-02-23 11:13:18
Aviculin, a lignan glycoside, is a potent anticancer agent. Aviculin reduces metabolic activity on MCF-7 cells below 50%, with an IC50 of 75.47 μM. Aviculin induces breast cancer cell apoptosis through the intrinsic apoptosis pathway. Aviculin increases expression of initiator caspase-9, executioner caspase-7, and poly (ADP-ribose) polymerase (PARP). Aviculin shows an increase in the Bax/Bcl-2 ratio[1].

Name	Aviculin

Description	Aviculin, a lignan glycoside, is a potent anticancer agent. Aviculin reduces metabolic activity on MCF-7 cells below 50%, with an IC50 of 75.47 μM. Aviculin induces breast cancer cell apoptosis through the intrinsic apoptosis pathway. Aviculin increases expression of initiator caspase-9, executioner caspase-7, and poly (ADP-ribose) polymerase (PARP). Aviculin shows an increase in the Bax/Bcl-2 ratio[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Apoptosis >> Caspase Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
Target	Caspase-9 Caspase-7 Bcl-2 Bax PARP
References	[1]. Lee D, et al. Aviculin Isolated from Lespedeza cuneata Induce Apoptosis in Breast Cancer Cells through Mitochondria-Mediated Caspase Activation Pathway. Molecules. 2020 Apr 8;25(7):1708.

Molecular Formula	C₂₆H₃₄O₁₀
Molecular Weight	506.54