2459489-66-6

2459489-66-6 structure

Name: NTQ1062
Chemical Name: NTQ1062
CAS Number: 2459489-66-6
Molecular Formula: C₂₅H₃₁ClN₆O₂
Molecular Weight: 483.01
Catalog: Signaling Pathways PI3K/Akt/mTOR Akt
Create Date: 2022-08-15 18:33:38
Modify Date: 2024-01-02 16:10:03
NTQ1062 (compound 22b) is a potent and orally active Akt inhibitor with IC50s of 0.4 nM, 6.3 nM and 0.1 nM for Akt1, Akt2 and Akt3, respectively. NTQ1062 induces cell apoptosis and arrests the cell cycle at G0/G1 phase. NTQ1062 exhibits antiproliferation activity against various cancer cells. NTQ1062 exhibits potent antitumor efficacy in LNCap xenograft mouse model[1].

Name	NTQ1062

Description	NTQ1062 (compound 22b) is a potent and orally active Akt inhibitor with IC50s of 0.4 nM, 6.3 nM and 0.1 nM for Akt1, Akt2 and Akt3, respectively. NTQ1062 induces cell apoptosis and arrests the cell cycle at G0/G1 phase. NTQ1062 exhibits antiproliferation activity against various cancer cells. NTQ1062 exhibits potent antitumor efficacy in LNCap xenograft mouse model[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Target	Akt1:0.4 nM (IC50) Akt2:6.3 nM (IC50) Akt3:0.1 nM (IC50)
In Vivo	Pharmacokinetic Parameters of NTQ1062 in male Sprague-Dawley rats[1]. IV (5 mg/kg) IG (10 mg/kg) Tmax (h) 2 t1/2 (ng/mL) 2.97 3.28 Cmax (ng/mL) 1691 705 AUC0-t (ng/mL·h) 1761 3877 AUC0-∞ (ng/mL·h) 1801 3891 VSS (L/kg) 7.76 F (%) 110
References	[1]. Ma C, et al. Discovery of Clinical Candidate NTQ1062 as a Potent and Bioavailable Akt Inhibitor for the Treatment of Human Tumors. J Med Chem. 2022 Jun 23;65(12):8144-8168.

Molecular Formula	C₂₅H₃₁ClN₆O₂
Molecular Weight	483.01